Next Article in Journal
Maternal Exposure to PM2.5 during Pregnancy Induces Impaired Development of Cerebral Cortex in Mice Offspring
Next Article in Special Issue
Emerging Roles of Tumor Necrosis Factor-Stimulated Gene-6 in the Pathophysiology and Treatment of Atherosclerosis
Previous Article in Journal
Synergistic Effects of Copper Sites on Apparent Stability of Multicopper Oxidase, Fet3p
Previous Article in Special Issue
New Insights into the Role of Inflammation in the Pathogenesis of Atherosclerosis
Letter published on 29 September 2018, see Int. J. Mol. Sci. 2018, 19(10), 2971.
Article

Cytokine Disturbances in Coronary Artery Ectasia Do Not Support Atherosclerosis Pathogenesis

1
Department of Public Health and Clinical Medicine, Umeå University, 901 87 Umeå, Sweden
2
Cardiology Department, Letterkenny University Hospital, Letterkenny, F92 AE81, Co. Donegal, Ireland
3
Molecular Periodontology and Odontology, Umeå University, 901 87 Umeå, Sweden
4
Department of Radiation Sciences, Umeå University, 901 87 Umeå, Sweden
5
Molecular & Clinical Sciences Research Institute, St. George University, London SW17 0RE, UK
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2018, 19(1), 260; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms19010260
Received: 28 October 2017 / Revised: 10 January 2018 / Accepted: 15 January 2018 / Published: 16 January 2018
(This article belongs to the Special Issue Pathomechanisms of Atherosclerosis. Part I)
Background: Coronary artery ectasia (CAE) is a rare disorder commonly associated with additional features of atherosclerosis. In the present study, we aimed to examine the systemic immune-inflammatory response that might associate CAE. Methods: Plasma samples were obtained from 16 patients with coronary artery ectasia (mean age 64.9 ± 7.3 years, 6 female), 69 patients with coronary artery disease (CAD) and angiographic evidence for atherosclerosis (age 64.5 ± 8.7 years, 41 female), and 140 controls (mean age 58.6 ± 4.1 years, 40 female) with normal coronary arteries. Samples were analyzed at Umeå University Biochemistry Laboratory, Sweden, using the V-PLEX Pro-Inflammatory Panel 1 (human) Kit. Statistically significant differences (p < 0.05) between patient groups and controls were determined using Mann–Whitney U-tests. Results: The CAE patients had significantly higher plasma levels of INF-γ, TNF-α, IL-1β, and IL-8 (p = 0.007, 0.01, 0.001, and 0.002, respectively), and lower levels of IL-2 and IL-4 (p < 0.001 for both) compared to CAD patients and controls. The plasma levels of IL-10, IL-12p, and IL-13 were not different between the three groups. None of these markers could differentiate between patients with pure (n = 6) and mixed with minimal atherosclerosis (n = 10) CAE. Conclusions: These results indicate an enhanced systemic pro-inflammatory response in CAE. The profile of this response indicates activation of macrophages through a pathway and trigger different from those of atherosclerosis immune inflammatory response. View Full-Text
Keywords: coronary artery ectasia; atherosclerosis; cytokines; macrophage activation; immune inflammatory response; coronary artery disease coronary artery ectasia; atherosclerosis; cytokines; macrophage activation; immune inflammatory response; coronary artery disease
Show Figures

Figure 1

MDPI and ACS Style

Boles, U.; Johansson, A.; Wiklund, U.; Sharif, Z.; David, S.; McGrory, S.; Henein, M.Y. Cytokine Disturbances in Coronary Artery Ectasia Do Not Support Atherosclerosis Pathogenesis. Int. J. Mol. Sci. 2018, 19, 260. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms19010260

AMA Style

Boles U, Johansson A, Wiklund U, Sharif Z, David S, McGrory S, Henein MY. Cytokine Disturbances in Coronary Artery Ectasia Do Not Support Atherosclerosis Pathogenesis. International Journal of Molecular Sciences. 2018; 19(1):260. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms19010260

Chicago/Turabian Style

Boles, Usama, Anders Johansson, Urban Wiklund, Zain Sharif, Santhosh David, Siobhan McGrory, and Michael Y. Henein 2018. "Cytokine Disturbances in Coronary Artery Ectasia Do Not Support Atherosclerosis Pathogenesis" International Journal of Molecular Sciences 19, no. 1: 260. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms19010260

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop