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Review

Molecular and Clinical Issues about the Risk of Venous Thromboembolism in Older Patients: A Focus on Parkinson’s Disease and Parkinsonism

1
Internal Medicine and Critical Subacute Care Unit, Medicine and Geriatric-Rehabilitation Department, University-Hospital of Parma, 43126 Parma, Italy
2
Department of Medicine and Surgery, University-Hospital of Parma, 43126 Parma, Italy
3
Cognitive and Motor Center, Medicine and Geriatric-Rehabilitation Department of Parma, University-Hospital of Parma, 43126 Parma, Italy
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2018, 19(5), 1299; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms19051299
Received: 19 March 2018 / Revised: 18 April 2018 / Accepted: 24 April 2018 / Published: 26 April 2018
(This article belongs to the Special Issue Molecular Research on Chronic Venous Disease)
Venous thromboembolism (VTE) is a common and potentially life-threatening condition which includes both deep-vein thrombosis (DVT) and pulmonary embolism (PE). VTE has a significant clinical and epidemiological impact in the elderly, and its incidence increases to more than 1% per year in older patients, suggesting the presence of specific age-related risk factors in this population. Immobilization seems to predominate as the main cause in patients admitted for medical acute illness in medicine wards, and there is evidence of a high risk in older patients with immobilization resulting from advanced forms of Parkinson’s disease (PD), regardless of the presence of an acute medical condition. In this review, we would to discuss the recent evidence on clinical, molecular and epidemiological features of VTE in older frail subjects focusing on patients with PD and parkinsonism. We also discuss some therapeutic issues about the risk prevention and we suggest a thorough comprehensive geriatric assessment that can represent an optimal strategy to identify and prevent the VTE risk in these patients. View Full-Text
Keywords: venous; thromboembolism; risk; old; frail; patients venous; thromboembolism; risk; old; frail; patients
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MDPI and ACS Style

Tana, C.; Lauretani, F.; Ticinesi, A.; Prati, B.; Nouvenne, A.; Meschi, T. Molecular and Clinical Issues about the Risk of Venous Thromboembolism in Older Patients: A Focus on Parkinson’s Disease and Parkinsonism. Int. J. Mol. Sci. 2018, 19, 1299. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms19051299

AMA Style

Tana C, Lauretani F, Ticinesi A, Prati B, Nouvenne A, Meschi T. Molecular and Clinical Issues about the Risk of Venous Thromboembolism in Older Patients: A Focus on Parkinson’s Disease and Parkinsonism. International Journal of Molecular Sciences. 2018; 19(5):1299. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms19051299

Chicago/Turabian Style

Tana, Claudio, Fulvio Lauretani, Andrea Ticinesi, Beatrice Prati, Antonio Nouvenne, and Tiziana Meschi. 2018. "Molecular and Clinical Issues about the Risk of Venous Thromboembolism in Older Patients: A Focus on Parkinson’s Disease and Parkinsonism" International Journal of Molecular Sciences 19, no. 5: 1299. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms19051299

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