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Article

Biotransformation of α-Acetylbutyrolactone in Rhodotorula Strains

1
Department of Chemistry, Wrocław University of Environmental and Life Sciences, Norwida 25, 50-375 Wrocław, Poland
2
Department of Biotechnology and Food Microbiology, Wrocław University of Environmental and Life Sciences, Chełmońskiego 37/41, 51-630 Wrocław, Poland
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2018, 19(7), 2106; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms19072106
Received: 5 July 2018 / Revised: 16 July 2018 / Accepted: 17 July 2018 / Published: 20 July 2018
(This article belongs to the Section Bioactives and Nutraceuticals)
Due to its structural similarity, the α’-1′-hydroxyethyl-γ-butyrolactone obtained by reduction of (±)-α-acetyl-γ-butyrolactone may have a similar function in the body to γ-butyrolactone (GBL). In the work presented, biotransformation of α-acetyl-γ-butyrolactone by three Rhodotorula strains was performed obtaining enantiomerically enriched alcohol. The process was carried out in growing and resting cultures. We studied how both media composition and organic solvent volume affected stereoselectivity and effectiveness of biotransformation. After 2 h, the enantiomerically pure (3R, 1′S)-α’-1′-hydroxyethyl-γ-butyrolactone was obtained using the R. marina AM77 strain in YPG (Yeast extract-Peptone-Glucose) medium enriched with 5% glycerol. To our best knowledge there is no previous information in the literature about the (±)-α-acetyl-γ-butyrolactone biotransformation performed in medium with addition of organic and deep eutectic solvents. View Full-Text
Keywords: yeast; biotransformation; lactone; DES; glycerol yeast; biotransformation; lactone; DES; glycerol
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MDPI and ACS Style

Mączka, W.; Wińska, K.; Grabarczyk, M.; Żarowska, B. Biotransformation of α-Acetylbutyrolactone in Rhodotorula Strains. Int. J. Mol. Sci. 2018, 19, 2106. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms19072106

AMA Style

Mączka W, Wińska K, Grabarczyk M, Żarowska B. Biotransformation of α-Acetylbutyrolactone in Rhodotorula Strains. International Journal of Molecular Sciences. 2018; 19(7):2106. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms19072106

Chicago/Turabian Style

Mączka, Wanda, Katarzyna Wińska, Małgorzata Grabarczyk, and Barbara Żarowska. 2018. "Biotransformation of α-Acetylbutyrolactone in Rhodotorula Strains" International Journal of Molecular Sciences 19, no. 7: 2106. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms19072106

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