Next Article in Journal
Polyphenols Derived from Lychee Seed Suppress Aβ (1-42)-Induced Neuroinflammation
Next Article in Special Issue
STAT3 in Skeletal Muscle Function and Disorders
Previous Article in Journal
Immune-Related Functional Differential Gene Expression in Koi Carp (Cyprinus carpio) after Challenge with Aeromonas sobria
Previous Article in Special Issue
STAT3 in Tumor-Associated Myeloid Cells: Multitasking to Disrupt Immunity
Article

STAT3, a Hub Protein of Cellular Signaling Pathways, Is Triggered by β-Hexaclorocyclohexane

1
Department of Biochemical Sciences, A. Rossi Fanelli, Sapienza University, P.le A. Moro 5, 00185 Rome, Italy
2
Istituto Pasteur-Fondazione Cenci Bolognetti, Sapienza University, P.le A. Moro 5, 00185 Rome, Italy
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2018, 19(7), 2108; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms19072108
Received: 26 June 2018 / Accepted: 17 July 2018 / Published: 20 July 2018
(This article belongs to the Special Issue Advances in Biological Functions of STAT3)
Background: Organochlorine pesticides (OCPs) are widely distributed in the environment and their toxicity is mostly associated with the molecular mechanisms of endocrine disruption. Among OCPs, particular attention was focused on the effects of β-hexaclorocyclohexane (β-HCH), a widely common pollutant. A detailed epidemiological study carried out on exposed population in the “Valle del Sacco” found correlations between the incidence of a wide range of diseases and the occurrence of β-HCH contamination. Taking into account the pleiotropic role of the protein signal transducer and activator of transcription 3 (STAT3), its function as a hub protein in cellular signaling pathways triggered by β-HCH was investigated in different cell lines corresponding to tissues that are especially vulnerable to damage by environmental pollutants. Materials and Methods: Human prostate cancer (LNCaP), human breast cancer (MCF-7 and MDA-MB 468), and human hepatoma (HepG2) cell lines were treated with 10 μM β-HCH in the presence or absence of specific inhibitors for different receptors. All samples were subjected to analysis by immunoblotting and RT-qPCR. Results and Conclusions: The preliminary results allow us to hypothesize the involvement of STAT3, through both its canonical and non-canonical pathways, in response to β-HCH. Moreover, we ascertained the role of STAT3 as a master regulator of energy metabolism via the altered expression and localization of HIF-1α and PKM2, respectively, resulting in a Warburg-like effect. View Full-Text
Keywords: STAT3; β-hexaclorocyclohexane (β-HCH); signal transduction; energy metabolism STAT3; β-hexaclorocyclohexane (β-HCH); signal transduction; energy metabolism
Show Figures

Graphical abstract

MDPI and ACS Style

Rubini, E.; Altieri, F.; Chichiarelli, S.; Giamogante, F.; Carissimi, S.; Paglia, G.; Macone, A.; Eufemi, M. STAT3, a Hub Protein of Cellular Signaling Pathways, Is Triggered by β-Hexaclorocyclohexane. Int. J. Mol. Sci. 2018, 19, 2108. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms19072108

AMA Style

Rubini E, Altieri F, Chichiarelli S, Giamogante F, Carissimi S, Paglia G, Macone A, Eufemi M. STAT3, a Hub Protein of Cellular Signaling Pathways, Is Triggered by β-Hexaclorocyclohexane. International Journal of Molecular Sciences. 2018; 19(7):2108. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms19072108

Chicago/Turabian Style

Rubini, Elisabetta, Fabio Altieri, Silvia Chichiarelli, Flavia Giamogante, Stefania Carissimi, Giuliano Paglia, Alberto Macone, and Margherita Eufemi. 2018. "STAT3, a Hub Protein of Cellular Signaling Pathways, Is Triggered by β-Hexaclorocyclohexane" International Journal of Molecular Sciences 19, no. 7: 2108. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms19072108

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop