Next Article in Journal
Calcineurin B-Like Proteins CBL4 and CBL10 Mediate Two Independent Salt Tolerance Pathways in Arabidopsis
Next Article in Special Issue
Green Tea Ameliorates Hyperglycemia by Promoting the Translocation of Glucose Transporter 4 in the Skeletal Muscle of Diabetic Rodents
Previous Article in Journal
Curcumin and Heme Oxygenase: Neuroprotection and Beyond
Previous Article in Special Issue
Antioxidant and Photoprotective Activity of Apigenin and its Potassium Salt Derivative in Human Keratinocytes and Absorption in Caco-2 Cell Monolayers
Review

Molecular Targets of Genistein and Its Related Flavonoids to Exert Anticancer Effects

1
College of Pharmacy, Dongguk University-Seoul, Goyang, Gyeonggi-do 10326, Korea
2
Department of Pharmacy, College of Pharmacy, Institute of Pharmaceutical Science and Technology, Hanyang University, Ansan, Gyeonggi-do 15588, Korea
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Int. J. Mol. Sci. 2019, 20(10), 2420; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms20102420
Received: 29 March 2019 / Revised: 30 April 2019 / Accepted: 9 May 2019 / Published: 16 May 2019
(This article belongs to the Special Issue Perspectives on the Health Benefits of Flavonoids)
Increased health awareness among the public has highlighted the health benefits of dietary supplements including flavonoids. As flavonoids target several critical factors to exert a variety of biological effects, studies to identify their target-specific effects have been conducted. Herein, we discuss the basic structures of flavonoids and their anticancer activities in relation to the specific biological targets acted upon by these flavonoids. Flavonoids target several signaling pathways involved in apoptosis, cell cycle arrest, mitogen-activated protein kinase (MAPK), phosphoinositide 3-kinase (PI3K)/AKT kinase, and metastasis. Polo-like kinase 1 (PLK1) has been recognized as a valuable target in cancer treatment due to the prognostic implication of PLK1 in cancer patients and its clinical relevance between the overexpression of PLK1 and the reduced survival rates of several carcinoma patients. Recent studies suggest that several flavonoids, including genistein directly inhibit PLK1 inhibitory activity. Later, we focus on the anticancer effects of genistein through inhibition of PLK1. View Full-Text
Keywords: flavonoid; genistein; PLK1; anticancer flavonoid; genistein; PLK1; anticancer
Show Figures

Figure 1

MDPI and ACS Style

Chae, H.-S.; Xu, R.; Won, J.-Y.; Chin, Y.-W.; Yim, H. Molecular Targets of Genistein and Its Related Flavonoids to Exert Anticancer Effects. Int. J. Mol. Sci. 2019, 20, 2420. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms20102420

AMA Style

Chae H-S, Xu R, Won J-Y, Chin Y-W, Yim H. Molecular Targets of Genistein and Its Related Flavonoids to Exert Anticancer Effects. International Journal of Molecular Sciences. 2019; 20(10):2420. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms20102420

Chicago/Turabian Style

Chae, Hee-Sung; Xu, Rong; Won, Jae-Yeon; Chin, Young-Won; Yim, Hyungshin. 2019. "Molecular Targets of Genistein and Its Related Flavonoids to Exert Anticancer Effects" Int. J. Mol. Sci. 20, no. 10: 2420. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms20102420

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop