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Hypoxia-Induced Epithelial-To-Mesenchymal Transition Mediates Fibroblast Abnormalities via ERK Activation in Cutaneous Wound Healing
Review

ERK Pathway in Activated, Myofibroblast-Like, Hepatic Stellate Cells: A Critical Signaling Crossroad Sustaining Liver Fibrosis

Department Clinical and Biological Sciences, Unit of Experimental Medicine and Clinical Pathology, University of Torino, Corso Raffaello 30, 10125 Torino, Italy
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Int. J. Mol. Sci. 2019, 20(11), 2700; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms20112700
Received: 7 May 2019 / Revised: 21 May 2019 / Accepted: 30 May 2019 / Published: 1 June 2019
(This article belongs to the Special Issue ERK Signaling Pathway in Diseases)
Fibrogenic progression of chronic liver disease, whatever the etiology, is characterized by persistent chronic parenchymal injury, chronic activation of inflammatory response, and sustained activation of liver fibrogenesis, and of pathological wound healing response. A critical role in liver fibrogenesis is played by hepatic myofibroblasts (MFs), a heterogeneous population of α smooth-muscle actin—positive cells that originate from various precursor cells through a process of activation and transdifferentiation. In this review, we focus the attention on the role of extracellular signal-regulated kinase (ERK) signaling pathway as a critical one in modulating selected profibrogenic phenotypic responses operated by liver MFs. We will also analyze major therapeutic antifibrotic strategies developed in the last two decades in preclinical studies, some translated to clinical conditions, designed to interfere directly or indirectly with the Ras/Raf/MEK/ERK signaling pathway in activated hepatic MFs, but that also significantly increased our knowledge on the biology and pathobiology of these fascinating profibrogenic cells. View Full-Text
Keywords: ERK pathway; hepatic stellate cells; liver myofibroblasts; liver fibrosis; chronic liver diseases; antifibrotic strategies ERK pathway; hepatic stellate cells; liver myofibroblasts; liver fibrosis; chronic liver diseases; antifibrotic strategies
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MDPI and ACS Style

Foglia, B.; Cannito, S.; Bocca, C.; Parola, M.; Novo, E. ERK Pathway in Activated, Myofibroblast-Like, Hepatic Stellate Cells: A Critical Signaling Crossroad Sustaining Liver Fibrosis. Int. J. Mol. Sci. 2019, 20, 2700. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms20112700

AMA Style

Foglia B, Cannito S, Bocca C, Parola M, Novo E. ERK Pathway in Activated, Myofibroblast-Like, Hepatic Stellate Cells: A Critical Signaling Crossroad Sustaining Liver Fibrosis. International Journal of Molecular Sciences. 2019; 20(11):2700. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms20112700

Chicago/Turabian Style

Foglia, Beatrice, Stefania Cannito, Claudia Bocca, Maurizio Parola, and Erica Novo. 2019. "ERK Pathway in Activated, Myofibroblast-Like, Hepatic Stellate Cells: A Critical Signaling Crossroad Sustaining Liver Fibrosis" International Journal of Molecular Sciences 20, no. 11: 2700. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms20112700

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