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E-cadherin Beyond Structure: A Signaling Hub in Colon Homeostasis and Disease

Department of Regenerative Medicine and Cell Biology, Medical University of South Carolina, 173 Ashley Avenue, Charleston, SC 29425, USA
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Int. J. Mol. Sci. 2019, 20(11), 2756; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms20112756
Received: 1 May 2019 / Revised: 27 May 2019 / Accepted: 1 June 2019 / Published: 5 June 2019
(This article belongs to the Special Issue Activations of Cadherin Signaling in Cancer)
E-cadherin is the core component of epithelial adherens junctions, essential for tissue development, differentiation, and maintenance. It is also fundamental for tissue barrier formation, a critical function of epithelial tissues. The colon or large intestine is lined by an epithelial monolayer that encompasses an E-cadherin-dependent barrier, critical for the homeostasis of the organ. Compromised barriers of the colonic epithelium lead to inflammation, fibrosis, and are commonly observed in colorectal cancer. In addition to its architectural role, E-cadherin is also considered a tumor suppressor in the colon, primarily a result of its opposing function to Wnt signaling, the predominant driver of colon tumorigenesis. Beyond these well-established traditional roles, several studies have portrayed an evolving role of E-cadherin as a signaling epicenter that regulates cell behavior in response to intra- and extra-cellular cues. Intriguingly, these recent findings also reveal tumor-promoting functions of E-cadherin in colon tumorigenesis and new interacting partners, opening future avenues of investigation. In this Review, we focus on these emerging aspects of E-cadherin signaling, and we discuss their implications in colon biology and disease. View Full-Text
Keywords: adherens junctions; CDH1; cadherin; catenin; colorectal cancer; inflammatory bowel disease; epithelial; colon crypt; microbiome adherens junctions; CDH1; cadherin; catenin; colorectal cancer; inflammatory bowel disease; epithelial; colon crypt; microbiome
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MDPI and ACS Style

Daulagala, A.C.; Bridges, M.C.; Kourtidis, A. E-cadherin Beyond Structure: A Signaling Hub in Colon Homeostasis and Disease. Int. J. Mol. Sci. 2019, 20, 2756. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms20112756

AMA Style

Daulagala AC, Bridges MC, Kourtidis A. E-cadherin Beyond Structure: A Signaling Hub in Colon Homeostasis and Disease. International Journal of Molecular Sciences. 2019; 20(11):2756. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms20112756

Chicago/Turabian Style

Daulagala, Amanda C.; Bridges, Mary C.; Kourtidis, Antonis. 2019. "E-cadherin Beyond Structure: A Signaling Hub in Colon Homeostasis and Disease" Int. J. Mol. Sci. 20, no. 11: 2756. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms20112756

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