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The Potential of Flavonoids for the Treatment of Neurodegenerative Diseases

Salk Institute for Biological Studies, La Jolla, CA 92037, USA
Int. J. Mol. Sci. 2019, 20(12), 3056; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms20123056
Received: 24 May 2019 / Revised: 7 June 2019 / Accepted: 18 June 2019 / Published: 22 June 2019
(This article belongs to the Special Issue Natural Products and Neuroprotection)
Neurodegenerative diseases, including Alzheimer’s disease (AD), Parkinson’s disease (PD), Huntington’s disease (HD), and amyotrophic lateral sclerosis (ALS), currently affect more than 6 million people in the United States. Unfortunately, there are no treatments that slow or prevent disease development and progression. Regardless of the underlying cause of the disorder, age is the strongest risk factor for developing these maladies, suggesting that changes that occur in the aging brain put it at increased risk for neurodegenerative disease development. Moreover, since there are a number of different changes that occur in the aging brain, it is unlikely that targeting a single change is going to be effective for disease treatment. Thus, compounds that have multiple biological activities that can impact the various age-associated changes in the brain that contribute to neurodegenerative disease development and progression are needed. The plant-derived flavonoids have a wide range of activities that could make them particularly effective for blocking the age-associated toxicity pathways associated with neurodegenerative diseases. In this review, the evidence for beneficial effects of multiple flavonoids in models of AD, PD, HD, and ALS is presented and common mechanisms of action are identified. Overall, the preclinical data strongly support further investigation of specific flavonoids for the treatment of neurodegenerative diseases. View Full-Text
Keywords: oxidative stress; cognitive dysfunction; inflammation; cell death; synapse loss; protein aggregation; neurodegenerative disease oxidative stress; cognitive dysfunction; inflammation; cell death; synapse loss; protein aggregation; neurodegenerative disease
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MDPI and ACS Style

Maher, P. The Potential of Flavonoids for the Treatment of Neurodegenerative Diseases. Int. J. Mol. Sci. 2019, 20, 3056. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms20123056

AMA Style

Maher P. The Potential of Flavonoids for the Treatment of Neurodegenerative Diseases. International Journal of Molecular Sciences. 2019; 20(12):3056. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms20123056

Chicago/Turabian Style

Maher, Pamela. 2019. "The Potential of Flavonoids for the Treatment of Neurodegenerative Diseases" Int. J. Mol. Sci. 20, no. 12: 3056. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms20123056

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