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Article

New Lectins from Mediterranean Flora. Activity against HT29 Colon Cancer Cells

1
Department of Toxicological and Bromatological Sciences (DCTB), Faculty of Pharmacy, Universidade de Lisboa, 1649-003 Lisboa, Portugal
2
Linking Landscape, Environment, Agriculture and Food (LEAF), Instituto Superior de Agronomia, Universidade de Lisboa, 1349-017y Lisboa, Portugal
3
Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, 1649-003 Lisboa, Portugal
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2019, 20(12), 3059; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms20123059
Received: 28 May 2019 / Revised: 19 June 2019 / Accepted: 20 June 2019 / Published: 22 June 2019
Experiments conducted in vitro and in vivo, as well as some preclinical trials for cancer therapeutics, support the antineoplastic properties of lectins. A screening of antitumoral activity on HT29 colon cancer cells, based on polypeptide characterization and specific lectin binding to HT29 cells membrane receptors, was performed in order to assess the bioactivities present in four Mediterranean plant species: Juniperus oxycedrus subsp. oxycedrus, Juniperus oxycedrus subsp. badia, Arbutus unedo and Corema album. Total leaf proteins from each species were evaluated with respect to cell viability and inhibitory activities on HT29 cells (cell migration, matrix metalloproteinase –MMP proteolytic activities). A discussion is presented on a possible mechanism justifying the specific binding of lectins to HT29 cell receptors. All species revealed the presence of proteins with affinity to HT29 cell glycosylated receptors, possibly explaining the differential antitumor activity exhibited by the two most promising species, Juniperus oxycedrus subsp. badia and Arbutus unedo. View Full-Text
Keywords: lectins; glycosylated receptors; HT29 colon cancer cells; antitumor activity lectins; glycosylated receptors; HT29 colon cancer cells; antitumor activity
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MDPI and ACS Style

Oliveira, I.; Nunes, A.; Lima, A.; Borralho, P.; Rodrigues, C.; Ferreira, R.B.; Ribeiro, A.C. New Lectins from Mediterranean Flora. Activity against HT29 Colon Cancer Cells. Int. J. Mol. Sci. 2019, 20, 3059. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms20123059

AMA Style

Oliveira I, Nunes A, Lima A, Borralho P, Rodrigues C, Ferreira RB, Ribeiro AC. New Lectins from Mediterranean Flora. Activity against HT29 Colon Cancer Cells. International Journal of Molecular Sciences. 2019; 20(12):3059. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms20123059

Chicago/Turabian Style

Oliveira, Isabel, António Nunes, Ana Lima, Pedro Borralho, Cecília Rodrigues, Ricardo B. Ferreira, and Ana C. Ribeiro 2019. "New Lectins from Mediterranean Flora. Activity against HT29 Colon Cancer Cells" International Journal of Molecular Sciences 20, no. 12: 3059. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms20123059

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