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The Potential of Flavonoids for the Treatment of Neurodegenerative Diseases

Anti-Inflammatory Activities of Marine Algae in Neurodegenerative Diseases

Department for Life Quality Studies, Alma Mater Studiorum-University of Bologna, 40126 Bologna, Italy
School of Pharmacy, University of Camerino, 62032 Camerino, Italy
Department of Clinical and Experimental Medicine, University of Pisa, Pisa 56126, Italy
Authors to whom correspondence should be addressed.
Int. J. Mol. Sci. 2019, 20(12), 3061;
Received: 31 May 2019 / Revised: 18 June 2019 / Accepted: 19 June 2019 / Published: 22 June 2019
(This article belongs to the Special Issue Natural Products and Neuroprotection)
Neuroinflammation is one of the main contributors to the onset and progression of neurodegenerative diseases such as Alzheimer’s and Parkinson’s diseases. Microglial and astrocyte activation is a brain defense mechanism to counteract harmful pathogens and damaged tissues, while their prolonged activation induces neuroinflammation that can trigger or exacerbate neurodegeneration. Unfortunately, to date there are no pharmacological therapies able to slow down or stop the progression of neurodegeneration. For this reason, research is turning to the identification of natural compounds with protective action against these diseases. Considering the important role of neuroinflammation in the onset and development of neurodegenerative pathologies, natural compounds with anti-inflammatory activity could be good candidates for developing effective therapeutic strategies. Marine organisms represent a huge source of natural compounds, and among them, algae are appreciated sources of important bioactive components such as antioxidants, proteins, vitamins, minerals, soluble dietary fibers, polyunsaturated fatty acids, polysaccharides, sterols, carotenoids, tocopherols, terpenes, phycobilins, phycocolloids, and phycocyanins. Recently, numerous anti-inflammatory compounds have been isolated from marine algae with potential protective efficacy against neuroinflammation. This review highlights the key inflammatory processes involved in neurodegeneration and the potential of specific compounds from marine algae to counteract neuroinflammation in the CNS. View Full-Text
Keywords: neuroinflammation; neurodegeneration; algae; seaweeds; neurodegenerative diseases neuroinflammation; neurodegeneration; algae; seaweeds; neurodegenerative diseases
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MDPI and ACS Style

Barbalace, M.C.; Malaguti, M.; Giusti, L.; Lucacchini, A.; Hrelia, S.; Angeloni, C. Anti-Inflammatory Activities of Marine Algae in Neurodegenerative Diseases. Int. J. Mol. Sci. 2019, 20, 3061.

AMA Style

Barbalace MC, Malaguti M, Giusti L, Lucacchini A, Hrelia S, Angeloni C. Anti-Inflammatory Activities of Marine Algae in Neurodegenerative Diseases. International Journal of Molecular Sciences. 2019; 20(12):3061.

Chicago/Turabian Style

Barbalace, Maria C., Marco Malaguti, Laura Giusti, Antonio Lucacchini, Silvana Hrelia, and Cristina Angeloni. 2019. "Anti-Inflammatory Activities of Marine Algae in Neurodegenerative Diseases" International Journal of Molecular Sciences 20, no. 12: 3061.

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