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Review

Carcinoembryonic Cell Adhesion-Related Molecule 2 Regulates Insulin Secretion and Energy Balance

1
Department of Biomedical Sciences, Heritage College of Osteopathic Medicine, Ohio University, Athens, OH 45701-2979, USA
2
Department of Zoology, Faculty of Science, Sohag University, Sohag 82524, Egypt
3
Diabetes Institute, Heritage College of Osteopathic Medicine, Ohio University, Athens, OH 45701-2979, USA
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2019, 20(13), 3231; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms20133231
Received: 17 May 2019 / Revised: 12 June 2019 / Accepted: 25 June 2019 / Published: 1 July 2019
The Carcinoembryonic Antigen-Related Cell Adhesion Molecule (CEACAM) family of proteins plays a significant role in regulating peripheral insulin action by participating in the regulation of insulin metabolism and energy balance. In light of their differential expression, CEACAM1 regulates chiefly insulin extraction, whereas CEACAM2 appears to play a more important role in regulating insulin secretion and overall energy balance, including food intake, energy expenditure and spontaneous physical activity. We will focus this review on the role of CEACAM2 in regulating insulin metabolism and energy balance with an overarching goal to emphasize the importance of the coordinated regulatory effect of these related plasma membrane glycoproteins on insulin metabolism and action. View Full-Text
Keywords: hyperinsulinemia; insulin clearance; insulin resistance; hyperphagia; energy balance hyperinsulinemia; insulin clearance; insulin resistance; hyperphagia; energy balance
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MDPI and ACS Style

Salaheldeen, E.; Jaume, A.; Michael Najjar, S. Carcinoembryonic Cell Adhesion-Related Molecule 2 Regulates Insulin Secretion and Energy Balance. Int. J. Mol. Sci. 2019, 20, 3231. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms20133231

AMA Style

Salaheldeen E, Jaume A, Michael Najjar S. Carcinoembryonic Cell Adhesion-Related Molecule 2 Regulates Insulin Secretion and Energy Balance. International Journal of Molecular Sciences. 2019; 20(13):3231. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms20133231

Chicago/Turabian Style

Salaheldeen, Elsaid, Alexa Jaume, and Sonia Michael Najjar. 2019. "Carcinoembryonic Cell Adhesion-Related Molecule 2 Regulates Insulin Secretion and Energy Balance" International Journal of Molecular Sciences 20, no. 13: 3231. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms20133231

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