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Review

Perspectives for Ezrin and Radixin in Astrocytes: Kinases, Functions and Pathology

1
Institute of Anatomy II, Goethe-University Frankfurt, D-60590 Frankfurt am Main, Germany
2
Neuropathology, Institute for Pathology, Carl Gustav Carus University Hospital, TU Dresden, D-01307 Dresden, Germany
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2019, 20(15), 3776; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms20153776
Received: 5 July 2019 / Revised: 30 July 2019 / Accepted: 31 July 2019 / Published: 2 August 2019
Astrocytes are increasingly perceived as active partners in physiological brain function and behaviour. The structural correlations of the glia–synaptic interaction are the peripheral astrocyte processes (PAPs), where ezrin and radixin, the two astrocytic members of the ezrin-radixin-moesin (ERM) family of proteins are preferentially localised. While the molecular mechanisms of ERM (in)activation appear universal, at least in mammalian cells, and have been studied in great detail, the actual ezrin and radixin kinases, phosphatases and binding partners appear cell type specific and may be multiplexed within a cell. In astrocytes, ezrin is involved in process motility, which can be stimulated by the neurotransmitter glutamate, through activation of the glial metabotropic glutamate receptors (mGluRs) 3 or 5. However, it has remained open how this mGluR stimulus is transduced to ezrin activation. Knowing upstream signals of ezrin activation, ezrin kinase(s), and membrane-bound binding partners of ezrin in astrocytes might open new approaches to the glial role in brain function. Ezrin has also been implicated in invasive behaviour of astrocytomas, and glial activation. Here, we review data pertaining to potential molecular interaction partners of ezrin in astrocytes, with a focus on PKC and GRK2, and in gliomas and other diseases, to stimulate further research on their potential roles in glia-synaptic physiology and pathology. View Full-Text
Keywords: radixin; ERM; phosphatases; mGluR3; mGluR5; PKCε; GRK2; astrocytoma; glioblastoma; epilepsy; glial activation radixin; ERM; phosphatases; mGluR3; mGluR5; PKCε; GRK2; astrocytoma; glioblastoma; epilepsy; glial activation
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MDPI and ACS Style

Derouiche, A.; Geiger, K.D. Perspectives for Ezrin and Radixin in Astrocytes: Kinases, Functions and Pathology. Int. J. Mol. Sci. 2019, 20, 3776. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms20153776

AMA Style

Derouiche A, Geiger KD. Perspectives for Ezrin and Radixin in Astrocytes: Kinases, Functions and Pathology. International Journal of Molecular Sciences. 2019; 20(15):3776. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms20153776

Chicago/Turabian Style

Derouiche, Amin, and Kathrin D. Geiger. 2019. "Perspectives for Ezrin and Radixin in Astrocytes: Kinases, Functions and Pathology" International Journal of Molecular Sciences 20, no. 15: 3776. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms20153776

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