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Article

Fucoxanthin-Rich Brown Algae Extract Improves Male Reproductive Function on Streptozotocin-Nicotinamide-Induced Diabetic Rat Model

1
Department of Food Science, National Taiwan Ocean University, Keelung 20224, Taiwan
2
Biotaiwan Foundation, New Taipei City 24886, Taiwan
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2019, 20(18), 4485; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms20184485
Received: 26 August 2019 / Revised: 9 September 2019 / Accepted: 10 September 2019 / Published: 11 September 2019
(This article belongs to the Special Issue Reproductive Immunology: Cellular and Molecular Biology)
Hypogonadism and oxidative stress are occurring commonly in men with diabetes and associated male infertility. This study aimed to investigate the capability of anti-oxidative and anti-inflammatory properties of fucoxanthin as well as to evaluate its protective effects on male reproduction in diabetic rats. The RAW 264.7 macrophage cells were used to evaluate the anti-oxidative and anti-inflammatory activity. Thirty male Sprague-Dawley rats were induced by streptozotocin-nicotinamide for a diabetes model and fed either with three different doses of fucoxanthin (13, 26, and 65 mg/kg) or rosiglitazone (0.571 mg/kg) for four weeks. The fucoxanthin significantly inhibited nitric oxide production and reduced reactive oxygen species level in lipopolysaccharide-induced RAW 264.7 cells. In the animal study, fucoxanthin administration improved insulin resistance, restored sperm motility, decreased abnormal sperm number, and inhibited lipid peroxidation. Moreover, it restored GPR54 and SOCS-3 mRNA expression in the hypothalamus and recovered luteinizing hormone level, as well as the testosterone level. In conclusion, fucoxanthin not only possessed antioxidant and anti-inflammatory properties but also decreased the diabetes signs and symptoms as well as improved spermatogenesis and male reproductive function. View Full-Text
Keywords: diabetes; fucoxanthin; hypogonadism; male reproduction; spermatogenesis diabetes; fucoxanthin; hypogonadism; male reproduction; spermatogenesis
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MDPI and ACS Style

Kong, Z.-L.; Sudirman, S.; Hsu, Y.-C.; Su, C.-Y.; Kuo, H.-P. Fucoxanthin-Rich Brown Algae Extract Improves Male Reproductive Function on Streptozotocin-Nicotinamide-Induced Diabetic Rat Model. Int. J. Mol. Sci. 2019, 20, 4485. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms20184485

AMA Style

Kong Z-L, Sudirman S, Hsu Y-C, Su C-Y, Kuo H-P. Fucoxanthin-Rich Brown Algae Extract Improves Male Reproductive Function on Streptozotocin-Nicotinamide-Induced Diabetic Rat Model. International Journal of Molecular Sciences. 2019; 20(18):4485. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms20184485

Chicago/Turabian Style

Kong, Zwe-Ling, Sabri Sudirman, Yu-Chun Hsu, Chieh-Yu Su, and Hsiang-Ping Kuo. 2019. "Fucoxanthin-Rich Brown Algae Extract Improves Male Reproductive Function on Streptozotocin-Nicotinamide-Induced Diabetic Rat Model" International Journal of Molecular Sciences 20, no. 18: 4485. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms20184485

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