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Natural Products as Modulators of the Proteostasis Machinery: Implications in Neurodegenerative Diseases

1
The Mitchell Center for Alzheimer′s Disease and Related Brain Disorders, Department of Neurology, The University of Texas Houston Health Science Center at Houston, Houston, TX 77030, USA
2
Departamento Biologia Celular, Genetica y Fisiologia, Instituto de Investigacion Biomedica de Malaga-IBIMA, Facultad de Ciencias, Universidad de Malaga, 28031 Madrid, Spain
3
Networking Research Center on Neurodegenerative Diseases (CIBERNED), 28031 Madrid, Spain
*
Authors to whom correspondence should be addressed.
Current address: Department of Molecular Biosciences, Rice Institute for Biomedical Research, Northwestern University, Evanston, IL 60208, USA.
Int. J. Mol. Sci. 2019, 20(19), 4666; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms20194666
Received: 28 August 2019 / Revised: 13 September 2019 / Accepted: 15 September 2019 / Published: 20 September 2019
(This article belongs to the Special Issue Natural Products and Neuroprotection)
Proteins play crucial and diverse roles within the cell. To exert their biological function they must fold to acquire an appropriate three-dimensional conformation. Once their function is fulfilled, they need to be properly degraded to hamper any possible damage. Protein homeostasis or proteostasis comprises a complex interconnected network that regulates different steps of the protein quality control, from synthesis and folding, to degradation. Due to the primary role of proteins in cellular function, the integrity of this network is critical to assure functionality and health across lifespan. Proteostasis failure has been reported in the context of aging and neurodegeneration, such as Alzheimer’s and Parkinson’s disease. Therefore, targeting the proteostasis elements emerges as a promising neuroprotective therapeutic approach to prevent or ameliorate the progression of these disorders. A variety of natural products are known to be neuroprotective by protein homeostasis interaction. In this review, we will focus on the current knowledge regarding the use of natural products as modulators of different components of the proteostasis machinery within the framework of age-associated neurodegenerative diseases. View Full-Text
Keywords: proteostasis; neurodegeneration; chaperones; autophagy; ubiquitin-proteasome; unfolded protein response; natural compounds proteostasis; neurodegeneration; chaperones; autophagy; ubiquitin-proteasome; unfolded protein response; natural compounds
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MDPI and ACS Style

Cuanalo-Contreras, K.; Moreno-Gonzalez, I. Natural Products as Modulators of the Proteostasis Machinery: Implications in Neurodegenerative Diseases. Int. J. Mol. Sci. 2019, 20, 4666. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms20194666

AMA Style

Cuanalo-Contreras K, Moreno-Gonzalez I. Natural Products as Modulators of the Proteostasis Machinery: Implications in Neurodegenerative Diseases. International Journal of Molecular Sciences. 2019; 20(19):4666. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms20194666

Chicago/Turabian Style

Cuanalo-Contreras, Karina; Moreno-Gonzalez, Ines. 2019. "Natural Products as Modulators of the Proteostasis Machinery: Implications in Neurodegenerative Diseases" Int. J. Mol. Sci. 20, no. 19: 4666. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms20194666

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