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Review

Amelioration of Mitochondrial Quality Control and Proteostasis by Natural Compounds in Parkinson’s Disease Models

by 1,†, 2,3,†, 2,3,†, 2,* and 1,3,*
1
Division of Biotechnology, Daegu Gyeongbuk Institute of Science and Technology, Daegu 42988, Korea
2
Department of New Biology, Daegu Gyeongbuk Institute of Science and Technology, Daegu 42988, Korea
3
Well Aging Research Center, Daegu Gyeongbuk Institute of Science and Technology, Daegu 42988, Korea
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Int. J. Mol. Sci. 2019, 20(20), 5208; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms20205208
Received: 4 October 2019 / Revised: 17 October 2019 / Accepted: 17 October 2019 / Published: 21 October 2019
(This article belongs to the Special Issue Natural Products and Neuroprotection)
Parkinson’s disease (PD) is a well-known age-related neurodegenerative disorder associated with longer lifespans and rapidly aging populations. The pathophysiological mechanism is a complex progress involving cellular damage such as mitochondrial dysfunction and protein homeostasis. Age-mediated degenerative neurological disorders can reduce the quality of life and also impose economic burdens. Currently, the common treatment is replacement with levodopa to address low dopamine levels; however, this does not halt the progression of PD and is associated with adverse effects, including dyskinesis. In addition, elderly patients can react negatively to treatment with synthetic neuroprotection agents. Recently, natural compounds such as phytochemicals with fewer side effects have been reported as candidate treatments of age-related neurodegenerative diseases. This review focuses on mitochondrial dysfunction, oxidative stress, hormesis, proteostasis, the ubiquitin‒proteasome system, and autophagy (mitophagy) to explain the neuroprotective effects of using natural products as a therapeutic strategy. We also summarize the efforts to use natural extracts to develop novel pharmacological candidates for treatment of age-related PD. View Full-Text
Keywords: Parkinson’s disease (PD); mitochondrial dysfunction; dynamics; hormesis; proteostasis; ubiquitin‒proteasome system (UPS); autophagy; mitophagy; natural compounds Parkinson’s disease (PD); mitochondrial dysfunction; dynamics; hormesis; proteostasis; ubiquitin‒proteasome system (UPS); autophagy; mitophagy; natural compounds
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MDPI and ACS Style

Cho, B.; Kim, T.; Huh, Y.-J.; Lee, J.; Lee, Y.-I. Amelioration of Mitochondrial Quality Control and Proteostasis by Natural Compounds in Parkinson’s Disease Models. Int. J. Mol. Sci. 2019, 20, 5208. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms20205208

AMA Style

Cho B, Kim T, Huh Y-J, Lee J, Lee Y-I. Amelioration of Mitochondrial Quality Control and Proteostasis by Natural Compounds in Parkinson’s Disease Models. International Journal of Molecular Sciences. 2019; 20(20):5208. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms20205208

Chicago/Turabian Style

Cho, Bongki, Taeyun Kim, Yu-Jin Huh, Jaemin Lee, and Yun-Il Lee. 2019. "Amelioration of Mitochondrial Quality Control and Proteostasis by Natural Compounds in Parkinson’s Disease Models" International Journal of Molecular Sciences 20, no. 20: 5208. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms20205208

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