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Heat Shock Proteins in Glioblastoma Biology: Where Do We Stand?

Department of Cell and Developmental Biology, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo 05508-000, Brazil
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Int. J. Mol. Sci. 2019, 20(22), 5794;
Received: 21 October 2019 / Revised: 15 November 2019 / Accepted: 16 November 2019 / Published: 18 November 2019
Heat shock proteins (HSPs) are evolutionary conserved proteins that work as molecular chaperones and perform broad and crucial roles in proteostasis, an important process to preserve the integrity of proteins in different cell types, in health and disease. Their function in cancer is an important aspect to be considered for a better understanding of disease development and progression. Glioblastoma (GBM) is the most frequent and lethal brain cancer, with no effective therapies. In recent years, HSPs have been considered as possible targets for GBM therapy due their importance in different mechanisms that govern GBM malignance. In this review, we address current evidence on the role of several HSPs in the biology of GBMs, and how these molecules have been considered in different treatments in the context of this disease, including their activities in glioblastoma stem-like cells (GSCs), a small subpopulation able to drive GBM growth. Additionally, we highlight recent works that approach other classes of chaperones, such as histone and mitochondrial chaperones, as important molecules for GBM aggressiveness. Herein, we provide new insights into how HSPs and their partners play pivotal roles in GBM biology and may open new therapeutic avenues for GBM based on proteostasis machinery. View Full-Text
Keywords: heat shock proteins; chaperones; glioblastoma; therapy; stem cells; proteostasis heat shock proteins; chaperones; glioblastoma; therapy; stem cells; proteostasis
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MDPI and ACS Style

Iglesia, R.P.; Fernandes, C.F.d.L.; Coelho, B.P.; Prado, M.B.; Melo Escobar, M.I.; Almeida, G.H.D.R.; Lopes, M.H. Heat Shock Proteins in Glioblastoma Biology: Where Do We Stand? Int. J. Mol. Sci. 2019, 20, 5794.

AMA Style

Iglesia RP, Fernandes CFdL, Coelho BP, Prado MB, Melo Escobar MI, Almeida GHDR, Lopes MH. Heat Shock Proteins in Glioblastoma Biology: Where Do We Stand? International Journal of Molecular Sciences. 2019; 20(22):5794.

Chicago/Turabian Style

Iglesia, Rebeca P., Camila F.d.L. Fernandes, Bárbara P. Coelho, Mariana B. Prado, Maria I. Melo Escobar, Gustavo H.D.R. Almeida, and Marilene H. Lopes 2019. "Heat Shock Proteins in Glioblastoma Biology: Where Do We Stand?" International Journal of Molecular Sciences 20, no. 22: 5794.

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