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Review

High Mobility Group Box-1 and Diabetes Mellitus Complications: State of the Art and Future Perspectives

1
U.O.C. Clinica Medica e Malattie Vascolari, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Roma, Italy
2
Laboratory of Vascular Biology and Genetics, Università Cattolica del Sacro Cuore, 00168 Roma, Italy
3
Università Cattolica del Sacro Cuore, 00168 Roma, Italy
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Int. J. Mol. Sci. 2019, 20(24), 6258; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms20246258
Received: 23 November 2019 / Revised: 8 December 2019 / Accepted: 9 December 2019 / Published: 11 December 2019
(This article belongs to the Special Issue HMG Proteins in Development and Disease)
Diabetes mellitus (DM) is an endemic disease, with growing health and social costs. The complications of diabetes can affect potentially all parts of the human body, from the heart to the kidneys, peripheral and central nervous system, and the vascular bed. Although many mechanisms have been studied, not all players responsible for these complications have been defined yet. High Mobility Group Box-1 (HMGB1) is a non-histone nuclear protein that has been implicated in many pathological processes, from sepsis to ischemia. The purpose of this review is to take stock of all the most recent data available on the role of HMGB1 in the complications of DM. View Full-Text
Keywords: High Mobility Group Box-1 (HMGB1), diabetes mellitus, vascular complications High Mobility Group Box-1 (HMGB1), diabetes mellitus, vascular complications
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MDPI and ACS Style

Biscetti, F.; Rando, M.M.; Nardella, E.; Cecchini, A.L.; Pecorini, G.; Landolfi, R.; Flex, A. High Mobility Group Box-1 and Diabetes Mellitus Complications: State of the Art and Future Perspectives. Int. J. Mol. Sci. 2019, 20, 6258. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms20246258

AMA Style

Biscetti F, Rando MM, Nardella E, Cecchini AL, Pecorini G, Landolfi R, Flex A. High Mobility Group Box-1 and Diabetes Mellitus Complications: State of the Art and Future Perspectives. International Journal of Molecular Sciences. 2019; 20(24):6258. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms20246258

Chicago/Turabian Style

Biscetti, Federico, Maria Margherita Rando, Elisabetta Nardella, Andrea Leonardo Cecchini, Giovanni Pecorini, Raffaele Landolfi, and Andrea Flex. 2019. "High Mobility Group Box-1 and Diabetes Mellitus Complications: State of the Art and Future Perspectives" International Journal of Molecular Sciences 20, no. 24: 6258. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms20246258

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