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Role of Immunogenetics in the Outcome of HCMV Infection: Implications for Ageing

Sezione di Patologia Generale, Dipartimento di Biomedicina, Neuroscienze e Diagnostica Avanzata, Università di Palermo, Corso Tukory 211, 90134 Palermo, Italy
Dipartimento di Scienze per la Promozione della Salute e Materno-Infantile, di Medicina Interna e Specialistica di Eccellenza “G. D’Alessandro”, Università di Palermo, Via del Vespro 129, 90127 Palermo, Italy
Dipartimento dell’Emergenza e dei Trapianti d’Organo, Università di Bari Aldo Moro, Piazza G. Cesare 11, 70124 Bari, Italy
Istituto di Biomedicina e Immunologia Molecolare, Consiglio Nazionale delle Ricerche, Via Ugo La Malfa 153, 90146 Palermo, Italy
Department of Microbiology and Immunology, Medical University of South Carolina, 171 Ashley Ave, Charleston, SC 29425, USA
Author to whom correspondence should be addressed.
These two authors contributed equally to this work.
Int. J. Mol. Sci. 2019, 20(3), 685;
Received: 17 January 2019 / Revised: 31 January 2019 / Accepted: 1 February 2019 / Published: 5 February 2019
The outcome of host-virus interactions is determined by a number of factors, some related to the virus, others to the host, such as environmental factors and genetic factors. Therefore, different individuals vary in their relative susceptibility to infections. Human cytomegalovirus (HCMV) is an important pathogen from a clinical point of view, as it causes significant morbidity and mortality in immunosuppressed or immunosenescent individuals, such as the transplanted patients and the elderly, respectively. It is, therefore, important to understand the mechanisms of virus infection control. In this review, we discuss recent advances in the immunobiology of HCMV-host interactions, with particular emphasis on the immunogenetic aspects (human leukocyte antigens, HLA; killer cell immunoglobulin-like receptors, KIRs; immunoglobulin genetic markers, GM allotypes) to elucidate the mechanisms underlying the complex host-virus interaction that determine various outcomes of HCMV infection. The results, which show the role of humoral and cellular immunity in the control of infection by HCMV, would be valuable in directing efforts to reduce HCMV spurred health complications in the transplanted patients and in the elderly, including immunosenescence. In addition, concerning GM allotypes, it is intriguing that, in a Southern Italian population, alleles associated with the risk of developing HCMV symptomatic infection are negatively associated with longevity. View Full-Text
Keywords: antibodies; elderly; GM; immunosenescence; HCMV; HLA; NK; KIR antibodies; elderly; GM; immunosenescence; HCMV; HLA; NK; KIR
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MDPI and ACS Style

Aiello, A.; Accardi, G.; Candore, G.; Caruso, C.; Colomba, C.; Di Bona, D.; Duro, G.; Gambino, C.M.; Ligotti, M.E.; Pandey, J.P. Role of Immunogenetics in the Outcome of HCMV Infection: Implications for Ageing. Int. J. Mol. Sci. 2019, 20, 685.

AMA Style

Aiello A, Accardi G, Candore G, Caruso C, Colomba C, Di Bona D, Duro G, Gambino CM, Ligotti ME, Pandey JP. Role of Immunogenetics in the Outcome of HCMV Infection: Implications for Ageing. International Journal of Molecular Sciences. 2019; 20(3):685.

Chicago/Turabian Style

Aiello, Anna, Giulia Accardi, Giuseppina Candore, Calogero Caruso, Claudia Colomba, Danilo Di Bona, Giovanni Duro, Caterina M. Gambino, Mattia E. Ligotti, and Janardan P. Pandey 2019. "Role of Immunogenetics in the Outcome of HCMV Infection: Implications for Ageing" International Journal of Molecular Sciences 20, no. 3: 685.

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