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Astrocytes in Flavivirus Infections

Laboratory of Neuroendocrinology—Molecular Cell Physiology, Institute of Pathophysiology, Faculty of Medicine, University of Ljubljana, Zaloška 4, 1000 Ljubljana, Slovenia
Celica BIOMEDICAL, Tehnološki park 24, 1000 Ljubljana, Slovenia
Authors to whom correspondence should be addressed.
Int. J. Mol. Sci. 2019, 20(3), 691;
Received: 8 January 2019 / Revised: 27 January 2019 / Accepted: 29 January 2019 / Published: 6 February 2019
Virus infections of the central nervous system (CNS) can manifest in various forms of inflammation, including that of the brain (encephalitis) and spinal cord (myelitis), all of which may have long-lasting deleterious consequences. Although the knowledge of how different viruses affect neural cells is increasing, understanding of the mechanisms by which cells respond to neurotropic viruses remains fragmented. Several virus types have the ability to infect neural tissue, and astrocytes, an abundant and heterogeneous neuroglial cell type and a key element providing CNS homeostasis, are one of the first CNS cell types to get infected. Astrocytes are morphologically closely aligned with neuronal synapses, blood vessels, and ventricle cavities, and thereby have the capacity to functionally interact with neurons and endothelial cells. In this review, we focus on the responses of astrocytes to infection by neurotropic flaviviruses, including tick-borne encephalitis virus (TBEV), Zika virus (ZIKV), West Nile virus (WNV), and Japanese encephalitis virus (JEV), which have all been confirmed to infect astrocytes and cause multiple CNS defects. Understanding these mechanisms may help design new strategies to better contain and mitigate virus- and astrocyte-dependent neuroinflammation. View Full-Text
Keywords: astrocytes; flavivirus; neuroinfections; TBEV; ZIKV; WNV; JEV; encephalitis astrocytes; flavivirus; neuroinfections; TBEV; ZIKV; WNV; JEV; encephalitis
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MDPI and ACS Style

Potokar, M.; Jorgačevski, J.; Zorec, R. Astrocytes in Flavivirus Infections. Int. J. Mol. Sci. 2019, 20, 691.

AMA Style

Potokar M, Jorgačevski J, Zorec R. Astrocytes in Flavivirus Infections. International Journal of Molecular Sciences. 2019; 20(3):691.

Chicago/Turabian Style

Potokar, Maja, Jernej Jorgačevski, and Robert Zorec. 2019. "Astrocytes in Flavivirus Infections" International Journal of Molecular Sciences 20, no. 3: 691.

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