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Transcriptomic Analysis of Planarians under Simulated Microgravity or 8 g Demonstrates That Alteration of Gravity Induces Genomic and Cellular Alterations That Could Facilitate Tumoral Transformation

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Department of Genetics, Microbiology and Statistics, and Institute of Biomedicine, University of Barcelona, Catalonia, 08028 Barcelona, Spain
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CNAG-CRG, Centre for Genomic Regulation (CRG), Barcelona Institute of Science and Technology (BIST), 08028 Barcelona, Spain
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Universitat Pompeu Fabra (UPF), 08002 Barcelona, Spain
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Pontifical University Antonianum, via Merulana 124, 00185 Rome, Italy
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Pontifical University of the Holy Cross, DISF Centre, Via dei Pianellari 41, 00186 Rome, Italy
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University of Cassino, Via Zamosch 43, 03043 Cassino, Italy
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Dutch Experiment Support Center (DESC), Department of Oral and Maxillofacial Surgery/Oral Pathology, Amsterdam UMC location VU University Medical Center & Academic Centre for Dentistry Amsterdam (ACTA), 1081 LA Amsterdam, The Netherlands
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European Space Agency-ESA-Technology Center-ESTEC, TEC-MMG-Lab, 2200 AG Noordwijk, The Netherlands
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Pontifical Gregorian University, Piazza della Pilotta 4, 00187 Roma, Italy
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Authors to whom correspondence should be addressed.
Int. J. Mol. Sci. 2019, 20(3), 720; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms20030720
Received: 27 December 2018 / Revised: 25 January 2019 / Accepted: 31 January 2019 / Published: 8 February 2019
(This article belongs to the Section Molecular Biology)
The possibility of humans to live outside of Earth on another planet has attracted the attention of numerous scientists around the world. One of the greatest difficulties is that humans cannot live in an extra-Earth environment without proper equipment. In addition, the consequences of chronic gravity alterations in human body are not known. Here, we used planarians as a model system to test how gravity fluctuations could affect complex organisms. Planarians are an ideal system, since they can regenerate any missing part and they are continuously renewing their tissues. We performed a transcriptomic analysis of animals submitted to simulated microgravity (Random Positioning Machine, RPM) (s-µg) and hypergravity (8 g), and we observed that the transcriptional levels of several genes are affected. Surprisingly, we found the major differences in the s-µg group. The results obtained in the transcriptomic analysis were validated, demonstrating that our transcriptomic data is reliable. We also found that, in a sensitive environment, as under Hippo signaling silencing, gravity fluctuations potentiate the increase in cell proliferation. Our data revealed that changes in gravity severely affect genetic transcription and that these alterations potentiate molecular disorders that could promote the development of multiple diseases such as cancer. View Full-Text
Keywords: development; hypergravity; human health; microgravity; planarian; regeneration; space exploration; transcriptomics; Random Positioning Machine (RPM), Large Diameter Centrifuge (LDC) development; hypergravity; human health; microgravity; planarian; regeneration; space exploration; transcriptomics; Random Positioning Machine (RPM), Large Diameter Centrifuge (LDC)
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MDPI and ACS Style

de Sousa, N.; Rodriguez-Esteban, G.; Colagè, I.; D’Ambrosio, P.; van Loon, J.J.W.A.; Saló, E.; Adell, T.; Auletta, G. Transcriptomic Analysis of Planarians under Simulated Microgravity or 8 g Demonstrates That Alteration of Gravity Induces Genomic and Cellular Alterations That Could Facilitate Tumoral Transformation. Int. J. Mol. Sci. 2019, 20, 720. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms20030720

AMA Style

de Sousa N, Rodriguez-Esteban G, Colagè I, D’Ambrosio P, van Loon JJWA, Saló E, Adell T, Auletta G. Transcriptomic Analysis of Planarians under Simulated Microgravity or 8 g Demonstrates That Alteration of Gravity Induces Genomic and Cellular Alterations That Could Facilitate Tumoral Transformation. International Journal of Molecular Sciences. 2019; 20(3):720. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms20030720

Chicago/Turabian Style

de Sousa, Nídia, Gustavo Rodriguez-Esteban, Ivan Colagè, Paolo D’Ambrosio, Jack J.W.A. van Loon, Emili Saló, Teresa Adell, and Gennaro Auletta. 2019. "Transcriptomic Analysis of Planarians under Simulated Microgravity or 8 g Demonstrates That Alteration of Gravity Induces Genomic and Cellular Alterations That Could Facilitate Tumoral Transformation" International Journal of Molecular Sciences 20, no. 3: 720. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms20030720

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