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Review

Effects of Chemotherapy and Radiotherapy on Spermatogenesis: The Role of Testicular Immunology

by 1,2,*, 2 and 1
1
Department of Anatomy, Division of Basic Medical Science, Tokai University School of Medicine, Kanagawa 259-1193, Japan
2
Department of Anatomy, Tokyo Medical University, Tokyo 160-8402, Japan
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2019, 20(4), 957; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms20040957
Received: 30 January 2019 / Revised: 20 February 2019 / Accepted: 20 February 2019 / Published: 22 February 2019
(This article belongs to the Special Issue Reproductive Immunology: Cellular and Molecular Biology)
Substantial improvements in cancer treatment have resulted in longer survival and increased quality of life in cancer survivors with minimized long-term toxicity. However, infertility and gonadal dysfunction continue to be recognized as adverse effects of anticancer therapy. In particular, alkylating agents and irradiation induce testicular damage that results in prolonged azoospermia. Although damage to and recovery of spermatogenesis after cancer treatment have been extensively studied, there is little information regarding the role of differences in testicular immunology in cancer treatment-induced male infertility. In this review, we briefly summarize available rodent and human data on immunological differences in chemotherapy or radiotherapy. View Full-Text
Keywords: male infertility; cancer; testicular immunology; azoospermia male infertility; cancer; testicular immunology; azoospermia
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MDPI and ACS Style

Qu, N.; Itoh, M.; Sakabe, K. Effects of Chemotherapy and Radiotherapy on Spermatogenesis: The Role of Testicular Immunology. Int. J. Mol. Sci. 2019, 20, 957. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms20040957

AMA Style

Qu N, Itoh M, Sakabe K. Effects of Chemotherapy and Radiotherapy on Spermatogenesis: The Role of Testicular Immunology. International Journal of Molecular Sciences. 2019; 20(4):957. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms20040957

Chicago/Turabian Style

Qu, Ning, Masahiro Itoh, and Kou Sakabe. 2019. "Effects of Chemotherapy and Radiotherapy on Spermatogenesis: The Role of Testicular Immunology" International Journal of Molecular Sciences 20, no. 4: 957. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms20040957

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