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Role of p90RSK in Kidney and Other Diseases

Department of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, 500 University Drive, Hershey, PA 17033, USA
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Int. J. Mol. Sci. 2019, 20(4), 972; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms20040972
Received: 29 January 2019 / Revised: 18 February 2019 / Accepted: 20 February 2019 / Published: 23 February 2019
(This article belongs to the Special Issue ERK Signaling Pathway in Diseases)
The 90 kDa ribosomal s6 kinases (RSKs) are a group of serine/threonine kinases consisting of 4 RSK isoforms (RSK1-4), of which RSK1 is also designated as p90RSK. p90RSK plays an important role in the Ras-mitogen-activated protein kinase (MAPK) signalling cascade and is the direct downstream effector of Ras-extracellular signal-regulated kinase (ERK1/2) signalling. ERK1/2 activation directly phosphorylates and activates p90RSK, which, in turn, activates various signalling events through selection of different phosphorylation substrates. Upregulation of p90RSK has been reported in numerous human diseases. p90RSK plays an important role in the regulation of diverse cellular processes. Thus, aberrant activation of p90RSK plays a critical role in the pathogenesis of organ dysfunction and damage. In this review, we focus on the current understanding of p90RSK functions and roles in the development and progression of kidney diseases. Roles of p90RSK, as well as other RSKs, in cardiovascular disorders and cancers are also discussed. View Full-Text
Keywords: p90RSK; signalling; kidney; atherosclerosis; kinase inhibitors; pathophysiology p90RSK; signalling; kidney; atherosclerosis; kinase inhibitors; pathophysiology
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MDPI and ACS Style

Lin, L.; White, S.A.; Hu, K. Role of p90RSK in Kidney and Other Diseases. Int. J. Mol. Sci. 2019, 20, 972. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms20040972

AMA Style

Lin L, White SA, Hu K. Role of p90RSK in Kidney and Other Diseases. International Journal of Molecular Sciences. 2019; 20(4):972. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms20040972

Chicago/Turabian Style

Lin, Ling, Samantha A. White, and Kebin Hu. 2019. "Role of p90RSK in Kidney and Other Diseases" International Journal of Molecular Sciences 20, no. 4: 972. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms20040972

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