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Review

Modulation of Obesity and Insulin Resistance by the Redox Enzyme and Adaptor Protein p66Shc

1
Veneto Institute of Molecular Medicine, 35128 Padova, Italy
2
Department of Medicine, University of Padova, 35128 Padova, Italy
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2019, 20(4), 985; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms20040985
Received: 1 February 2019 / Revised: 15 February 2019 / Accepted: 21 February 2019 / Published: 24 February 2019
Initially reported as a longevity-related protein, the 66 kDa isoform of the mammalian Shc1 locus has been implicated in several metabolic pathways, being able to act both as an adaptor protein and as a redox enzyme capable of generating reactive oxygen species (ROS) when it localizes to the mitochondrion. Ablation of p66Shc has been shown to be protective against obesity and the insurgence of insulin resistance, but not all the studies available in the literature agree on these points. This review will focus in particular on the role of p66Shc in the modulation of glucose homeostasis, obesity, body temperature, and respiration/energy expenditure. In view of the obesity and diabetes epidemic, p66Shc may represent a promising therapeutic target with enormous implications for human health. View Full-Text
Keywords: diabetes; metabolic syndrome; adipose tissue; muscle; glucose tolerance; aging; oxidative stress diabetes; metabolic syndrome; adipose tissue; muscle; glucose tolerance; aging; oxidative stress
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MDPI and ACS Style

Ciciliot, S.; Fadini, G.P. Modulation of Obesity and Insulin Resistance by the Redox Enzyme and Adaptor Protein p66Shc. Int. J. Mol. Sci. 2019, 20, 985. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms20040985

AMA Style

Ciciliot S, Fadini GP. Modulation of Obesity and Insulin Resistance by the Redox Enzyme and Adaptor Protein p66Shc. International Journal of Molecular Sciences. 2019; 20(4):985. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms20040985

Chicago/Turabian Style

Ciciliot, Stefano, and Gian P. Fadini 2019. "Modulation of Obesity and Insulin Resistance by the Redox Enzyme and Adaptor Protein p66Shc" International Journal of Molecular Sciences 20, no. 4: 985. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms20040985

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