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Facets of Theiler’s Murine Encephalomyelitis Virus-Induced Diseases: An Update
Article

Comparison of Reported Spinal Cord Lesions in Progressive Multiple Sclerosis with Theiler’s Murine Encephalomyelitis Virus Induced Demyelinating Disease

1
Department of Pathology, University of Veterinary Medicine Hannover, 30559 Hannover, Germany
2
Center for Systems Neuroscience, 30559 Hannover, Germany
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2019, 20(4), 989; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms20040989
Received: 26 December 2018 / Revised: 10 February 2019 / Accepted: 21 February 2019 / Published: 25 February 2019
Background: Spinal cord (SC) lesions in Theiler’s murine encephalomyelitis virus induced demyelinating disease (TMEV-IDD) resemble important features of brain lesions in progressive multiple sclerosis (MS) including inflammation, demyelination, and axonal damage. The aim of the present study was a comparison of SC lesions in MS and TMEV-IDD focusing on spatial and temporal distribution of demyelination, inflammation, SC atrophy (SCA), and axonal degeneration/loss in major descending motor pathways. Methods: TMEV and mock-infected mice were investigated clinically once a week. SC tissue was collected at 42, 98, 147, and 196 days post infection, and investigated using hematoxylin and eosin (HE) staining, immunohistochemistry targeting myelin basic protein (demyelination), Mac3 (microglia/macrophages), phosphorylated neurofilaments (axonal damage) and transmission electron microscopy. Results: Demyelination prevailed in SC white matter in TMEV-IDD, contrasting a predominant gray matter involvement in MS. TMEV-infected mice revealed a significant loss of axons similar to MS. Ultrastructural analysis in TMEV-IDD revealed denuded axons, degenerative myelin changes, axonal degeneration, as well as remyelination. SCA is a consistent finding in the SC of MS patients and was also detected at a late time point in TMEV-IDD. Conclusion: This comparative study further indicates the suitability of TMEV-IDD as animal model also for the investigation of progressive SC lesions in MS. View Full-Text
Keywords: axonal loss; multiple sclerosis; reticulospinal tract; spinal cord; spinal cord atrophy; Theiler’s murine encephalomyelitis virus axonal loss; multiple sclerosis; reticulospinal tract; spinal cord; spinal cord atrophy; Theiler’s murine encephalomyelitis virus
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MDPI and ACS Style

Leitzen, E.; Jin, W.; Herder, V.; Beineke, A.; Elmarabet, S.A.; Baumgärtner, W.; Hansmann, F. Comparison of Reported Spinal Cord Lesions in Progressive Multiple Sclerosis with Theiler’s Murine Encephalomyelitis Virus Induced Demyelinating Disease. Int. J. Mol. Sci. 2019, 20, 989. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms20040989

AMA Style

Leitzen E, Jin W, Herder V, Beineke A, Elmarabet SA, Baumgärtner W, Hansmann F. Comparison of Reported Spinal Cord Lesions in Progressive Multiple Sclerosis with Theiler’s Murine Encephalomyelitis Virus Induced Demyelinating Disease. International Journal of Molecular Sciences. 2019; 20(4):989. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms20040989

Chicago/Turabian Style

Leitzen, Eva, Wen Jin, Vanessa Herder, Andreas Beineke, Suliman A. Elmarabet, Wolfgang Baumgärtner, and Florian Hansmann. 2019. "Comparison of Reported Spinal Cord Lesions in Progressive Multiple Sclerosis with Theiler’s Murine Encephalomyelitis Virus Induced Demyelinating Disease" International Journal of Molecular Sciences 20, no. 4: 989. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms20040989

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