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Article

Reactive Species Interactome Alterations in Oocyte Donation Pregnancies in the Absence and Presence of Pre-Eclampsia

1
Department of Pathology, Leiden University Medical Center, 2333ZA Leiden, The Netherlands
2
Department of Obstetrics and Gynaecology, Leiden University Medical Center, 2333ZA Leiden, The Netherlands
3
Department of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, 9713 GZ Groningen, The Netherlands
4
Clinical & Experimental Sciences, Faculty of Medicine, University of Southampton and Southampton General Hospital, Southampton SO17 1BJ, UK
5
Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, 2333ZA Leiden, The Netherlands
6
Department of Obstetrics, University Medical Center Groningen, University of Groningen, 9713 GZ Groningen, The Netherlands
7
Department of Biomedical Research, University of Bern, 3012 Bern, Switzerland
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2019, 20(5), 1150; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms20051150
Received: 28 January 2019 / Revised: 20 February 2019 / Accepted: 26 February 2019 / Published: 6 March 2019
(This article belongs to the Special Issue Reproductive Immunology: Cellular and Molecular Biology)
In pregnancy, maternal physiology is subject to considerable adaptations, including alterations in cardiovascular and metabolic function as well as development of immunological tolerance towards the fetus. In an oocyte donation pregnancy, the fetus is fully allogeneic towards the mother, since it carries both oocyte donor antigens and paternal antigens. Therefore, oocyte donation pregnancies result in an immunologically challenging pregnancy, which is reflected by a higher-than-normal risk to develop pre-eclampsia. Based on the allogeneic conditions in oocyte donation pregnancies, we hypothesized that this situation may translate into alterations in concentration of stable readouts of constituents of the reactive species interactome (RSI) compared to normal pregnancies, especially serum free thiols, nitric oxide (NO) and hydrogen sulfide (H2S) related metabolites. Indeed, total free thiol levels and nitrite (NO2) concentrations were significantly lower whereas protein-bound NO and sulfate (SO42−) concentrations were significantly higher in both oocyte donation and naturally conceived pregnancies complicated by pre-eclampsia. The increased concentrations of nitrite observed in uncomplicated oocyte donation pregnancies suggest that endothelial NO production is compensatorily enhanced to lower vascular tone. More research is warranted on the role of the RSI and bioenergetic status in uncomplicated oocyte donation pregnancies and oocyte donation pregnancies complicated by pre-eclampsia. View Full-Text
Keywords: oocyte donation; reactive species interactome; thiols; nitric oxide; hydrogen sulfide; pre-eclampsia oocyte donation; reactive species interactome; thiols; nitric oxide; hydrogen sulfide; pre-eclampsia
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MDPI and ACS Style

Bos, M.; Schoots, M.H.; Fernandez, B.O.; Mikus-Lelinska, M.; Lau, L.C.; Eikmans, M.; van Goor, H.; Gordijn, S.J.; Pasch, A.; Feelisch, M.; van der Hoorn, M.-L.P. Reactive Species Interactome Alterations in Oocyte Donation Pregnancies in the Absence and Presence of Pre-Eclampsia. Int. J. Mol. Sci. 2019, 20, 1150. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms20051150

AMA Style

Bos M, Schoots MH, Fernandez BO, Mikus-Lelinska M, Lau LC, Eikmans M, van Goor H, Gordijn SJ, Pasch A, Feelisch M, van der Hoorn M-LP. Reactive Species Interactome Alterations in Oocyte Donation Pregnancies in the Absence and Presence of Pre-Eclampsia. International Journal of Molecular Sciences. 2019; 20(5):1150. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms20051150

Chicago/Turabian Style

Bos, Manon, Mirthe H. Schoots, Bernadette O. Fernandez, Monika Mikus-Lelinska, Laurie C. Lau, Michael Eikmans, Harry van Goor, Sanne J. Gordijn, Andreas Pasch, Martin Feelisch, and Marie-Louise P. van der Hoorn 2019. "Reactive Species Interactome Alterations in Oocyte Donation Pregnancies in the Absence and Presence of Pre-Eclampsia" International Journal of Molecular Sciences 20, no. 5: 1150. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms20051150

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