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Roles of Cyclic AMP Response Element Binding Activation in the ERK1/2 and p38 MAPK Signalling Pathway in Central Nervous System, Cardiovascular System, Osteoclast Differentiation and Mucin and Cytokine Production

Impact of ERK5 on the Hallmarks of Cancer

Tumor Cell Biology Unit–Core Research Laboratory, Institute for Cancer Research, Prevention and Clinical Network (ISPRO), V. le Pieraccini 6, 50139 Florence, Italy
Department of Experimental and Clinical Biomedical Sciences “Mario Serio”, University of Florence, Viale G. B. Morgagni 50, 50134 Florence, Italy
Authors to whom correspondence should be addressed.
Int. J. Mol. Sci. 2019, 20(6), 1426;
Received: 31 January 2019 / Revised: 15 March 2019 / Accepted: 18 March 2019 / Published: 21 March 2019
(This article belongs to the Special Issue ERK Signaling Pathway in Diseases)
Extracellular signal-regulated kinase 5 (ERK5) belongs to the mitogen-activated protein kinase (MAPK) family that consists of highly conserved enzymes expressed in all eukaryotic cells and elicits several biological responses, including cell survival, proliferation, migration, and differentiation. In recent years, accumulating lines of evidence point to a relevant role of ERK5 in the onset and progression of several types of cancer. In particular, it has been reported that ERK5 is a key signaling molecule involved in almost all the biological features of cancer cells so that its targeting is emerging as a promising strategy to suppress tumor growth and spreading. Based on that, in this review, we pinpoint the hallmark-specific role of ERK5 in cancer in order to identify biological features that will potentially benefit from ERK5 targeting. View Full-Text
Keywords: ERK5; BMK1; MAPK7; MEK5; cancer; cell proliferation; invasion; metastasis; apoptosis; targeted therapy ERK5; BMK1; MAPK7; MEK5; cancer; cell proliferation; invasion; metastasis; apoptosis; targeted therapy
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MDPI and ACS Style

Stecca, B.; Rovida, E. Impact of ERK5 on the Hallmarks of Cancer. Int. J. Mol. Sci. 2019, 20, 1426.

AMA Style

Stecca B, Rovida E. Impact of ERK5 on the Hallmarks of Cancer. International Journal of Molecular Sciences. 2019; 20(6):1426.

Chicago/Turabian Style

Stecca, Barbara, and Elisabetta Rovida. 2019. "Impact of ERK5 on the Hallmarks of Cancer" International Journal of Molecular Sciences 20, no. 6: 1426.

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