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Article

Dehydroabietic Acid Suppresses Inflammatory Response Via Suppression of Src-, Syk-, and TAK1-Mediated Pathways

1
Department of Integrative Biotechnology, Sungkyunkwan University, Suwon 16419, Korea
2
Basic Research & Innovation Division, R&D Center, AmorePacific Corporation, Yongin 17074, Korea
3
Colorectal Cancer Branch, Research Institute, National Cancer Center, Goyang 10408, Korea
4
Department of Physiology, College of Veterinary Medicine, Chonbuk National University, Iksan 54596, Korea
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Int. J. Mol. Sci. 2019, 20(7), 1593; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms20071593
Received: 14 March 2019 / Revised: 27 March 2019 / Accepted: 27 March 2019 / Published: 29 March 2019
(This article belongs to the Special Issue Nutraceuticals in Cancer and Disease Prevention)
Dehydroabietic acid (DAA) is a naturally occurring diterpene resin acid derived from coniferous plants such as Pinus and Picea. Various bioactive effects of DAA have been studied including antibacterial, antifungal, and anticancer activities. However, the anti-inflammatory mechanism of DAA remains unclear. We evaluated the anti-inflammatory effect of DAA in macrophage cell lines. Dehydroabietic acid clearly reduced nitric oxide (NO) production and inflammatory gene expression decreased according to RT-PCR results. Dehydroabietic acid displayed anti-inflammatory activity at the transcriptional level in results from NF-κB- or AP-1-mediated luciferase assays. To identify the DAA target protein, we investigated NF-κB and AP-1 pathways by Western blotting analysis. Dehydroabietic acid suppressed the activity of proto-oncogene tyrosine protein kinase (Src) and spleen tyrosine kinase (Syk) in the NF-κB cascade and transforming growth factor beta-activated kinase 1 (TAK1) in the AP-1 cascade. Using overexpression strategies, we confirmed that DAA targeted these kinases. Our findings demonstrate the anti-inflammatory effects and molecular mechanism of DAA. This suggests that DAA has potential as a drug or supplement to ameliorate inflammation. View Full-Text
Keywords: dehydroabietic acid (DAA); inflammation; NF-κB; AP-1 dehydroabietic acid (DAA); inflammation; NF-κB; AP-1
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MDPI and ACS Style

Kim, E.; Kang, Y.-G.; Kim, Y.-J.; Lee, T.R.; Yoo, B.C.; Jo, M.; Kim, J.H.; Kim, J.-H.; Kim, D.; Cho, J.Y. Dehydroabietic Acid Suppresses Inflammatory Response Via Suppression of Src-, Syk-, and TAK1-Mediated Pathways. Int. J. Mol. Sci. 2019, 20, 1593. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms20071593

AMA Style

Kim E, Kang Y-G, Kim Y-J, Lee TR, Yoo BC, Jo M, Kim JH, Kim J-H, Kim D, Cho JY. Dehydroabietic Acid Suppresses Inflammatory Response Via Suppression of Src-, Syk-, and TAK1-Mediated Pathways. International Journal of Molecular Sciences. 2019; 20(7):1593. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms20071593

Chicago/Turabian Style

Kim, Eunji, Young-Gyu Kang, Yong-Jin Kim, Tae R. Lee, Byong C. Yoo, Minkyeong Jo, Ji H. Kim, Jong-Hoon Kim, Donghyun Kim, and Jae Y. Cho 2019. "Dehydroabietic Acid Suppresses Inflammatory Response Via Suppression of Src-, Syk-, and TAK1-Mediated Pathways" International Journal of Molecular Sciences 20, no. 7: 1593. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms20071593

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