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Review

From Acellular Matrices to Smart Polymers: Degradable Scaffolds that are Transforming the Shape of Urethral Tissue Engineering

1
Laboratory for Stem Cell Research, Department of Health Science and Technology, Aalborg University, 9220 Aalborg, Denmark
2
Pediatric Surgery Department, Hamad General Hospital, 3050 Doha, Qatar
3
College of Medicine, Qatar University, 2713 Doha, Qatar
4
Surgery Department, Weill Cornell Medicine–Qatar, 24144 Doha, Qatar
5
Biomedical Research Center, Qatar University, 2713 Doha, Qatar
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2019, 20(7), 1763; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms20071763
Received: 18 January 2019 / Revised: 29 March 2019 / Accepted: 2 April 2019 / Published: 10 April 2019
(This article belongs to the Special Issue Cell-Biomaterial Interaction 2019)
Several congenital and acquired conditions may result in severe narrowing of the urethra in men, which represent an ongoing surgical challenge and a significant burden on both health and quality of life. In the field of urethral reconstruction, tissue engineering has emerged as a promising alternative to overcome some of the limitations associated with autologous tissue grafts. In this direction, preclinical as well as clinical studies, have shown that degradable scaffolds are able to restore the normal urethral architecture, supporting neo-vascularization and stratification of the tissue. While a wide variety of degradable biomaterials are under scrutiny, such as decellularized matrices, natural, and synthetic polymers, the search for scaffold materials that could fulfill the clinical performance requirements continues. In this article, we discuss the design requirements of the scaffold that appear to be crucial to better resemble the structural, physical, and biological properties of the native urethra and are expected to support an adequate recovery of the urethral function. In this context, we review the biological performance of the degradable polymers currently applied for urethral reconstruction and outline the perspectives on novel functional polymers, which could find application in the design of customized urethral constructs. View Full-Text
Keywords: urethral strictures; urethral tissue engineering; biodegradable polymers; acellular matrix; smart polymers urethral strictures; urethral tissue engineering; biodegradable polymers; acellular matrix; smart polymers
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MDPI and ACS Style

Abbas, T.O.; Yalcin, H.C.; Pennisi, C.P. From Acellular Matrices to Smart Polymers: Degradable Scaffolds that are Transforming the Shape of Urethral Tissue Engineering. Int. J. Mol. Sci. 2019, 20, 1763. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms20071763

AMA Style

Abbas TO, Yalcin HC, Pennisi CP. From Acellular Matrices to Smart Polymers: Degradable Scaffolds that are Transforming the Shape of Urethral Tissue Engineering. International Journal of Molecular Sciences. 2019; 20(7):1763. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms20071763

Chicago/Turabian Style

Abbas, Tariq O., Huseyin C. Yalcin, and Cristian P. Pennisi 2019. "From Acellular Matrices to Smart Polymers: Degradable Scaffolds that are Transforming the Shape of Urethral Tissue Engineering" International Journal of Molecular Sciences 20, no. 7: 1763. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms20071763

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