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Review

MAPK/ERK Signaling in Regulation of Renal Differentiation

by 1,2,†, 1,2,† and 1,2,3,*
1
Helsinki Institute of Life Science, University of Helsinki, FIN-00014 Helsinki, Finland
2
Stem Cells and Metabolism Research Program, Faculty of Medicine, University of Helsinki, FIN-00014 Helsinki, Finland
3
GM-Unit, Laboratory Animal Center, Helsinki Institute of Life Science, University of Helsinki, FIN-00014 Helsinki, Finland
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Int. J. Mol. Sci. 2019, 20(7), 1779; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms20071779
Received: 11 March 2019 / Revised: 4 April 2019 / Accepted: 8 April 2019 / Published: 10 April 2019
(This article belongs to the Special Issue ERK Signaling Pathway in Diseases)
Congenital anomalies of the kidney and urinary tract (CAKUT) are common birth defects derived from abnormalities in renal differentiation during embryogenesis. CAKUT is the major cause of end-stage renal disease and chronic kidney diseases in children, but its genetic causes remain largely unresolved. Here we discuss advances in the understanding of how mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK) activity contributes to the regulation of ureteric bud branching morphogenesis, which dictates the final size, shape, and nephron number of the kidney. Recent studies also demonstrate that the MAPK/ERK pathway is directly involved in nephrogenesis, regulating both the maintenance and differentiation of the nephrogenic mesenchyme. Interestingly, aberrant MAPK/ERK signaling is linked to many cancers, and recent studies suggest it also plays a role in the most common pediatric renal cancer, Wilms’ tumor. View Full-Text
Keywords: extracellular signal-regulated kinase; MAPK/ERK signaling; intracellular signaling; kidney development; ureteric bud branching morphogenesis; nephrogenesis; progenitor cells; self-renewal; differentiation extracellular signal-regulated kinase; MAPK/ERK signaling; intracellular signaling; kidney development; ureteric bud branching morphogenesis; nephrogenesis; progenitor cells; self-renewal; differentiation
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MDPI and ACS Style

Kurtzeborn, K.; Kwon, H.N.; Kuure, S. MAPK/ERK Signaling in Regulation of Renal Differentiation. Int. J. Mol. Sci. 2019, 20, 1779. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms20071779

AMA Style

Kurtzeborn K, Kwon HN, Kuure S. MAPK/ERK Signaling in Regulation of Renal Differentiation. International Journal of Molecular Sciences. 2019; 20(7):1779. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms20071779

Chicago/Turabian Style

Kurtzeborn, Kristen, Hyuk N. Kwon, and Satu Kuure. 2019. "MAPK/ERK Signaling in Regulation of Renal Differentiation" International Journal of Molecular Sciences 20, no. 7: 1779. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms20071779

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