Next Article in Journal
Altered Glutamate Receptor Ionotropic Delta Subunit 2 Expression in Stau2-Deficient Cerebellar Purkinje Cells in the Adult Brain
Next Article in Special Issue
STIM Proteins and Glutamate Receptors in Neurons: Role in Neuronal Physiology and Neurodegenerative Diseases
Previous Article in Journal
Bone Marrow Endothelial Cells Influence Function and Phenotype of Hematopoietic Stem and Progenitor Cells after Mixed Neutron/Gamma Radiation
Previous Article in Special Issue
Prophylactic Ketamine Treatment Promotes Resilience to Chronic Stress and Accelerates Recovery: Correlation with Changes in Synaptic Plasticity in the CA3 Subregion of the Hippocampus
Review

Glutamate Receptors and Glioblastoma Multiforme: An Old “Route” for New Perspectives

1
Department of Life Sciences, University of Modena and Reggio Emilia, Via G. Campi 287, 41125 Modena, Italy
2
CNR-Nanoscience Institute-S3, Via Campi 213/A, 41125 Modena, Italy
3
Department of Physics, Informatics e Mathematics, Via G. Campi 213/a, 41125 Modena, Italy
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2019, 20(7), 1796; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms20071796
Received: 21 March 2019 / Revised: 5 April 2019 / Accepted: 9 April 2019 / Published: 11 April 2019
(This article belongs to the Special Issue Glutamate Receptors in Health and Disease)
Glioblastoma multiforme (GBM) is the most aggressive malignant tumor of the central nervous system, with poor survival in both treated and untreated patients. Recent studies began to explain the molecular pathway, comprising the dynamic structural and mechanical changes involved in GBM. In this context, some studies showed that the human glioblastoma cells release high levels of glutamate, which regulates the proliferation and survival of neuronal progenitor cells. Considering that cancer cells possess properties in common with neural progenitor cells, it is likely that the functions of glutamate receptors may affect the growth of cancer cells and, therefore, open the road to new and more targeted therapies. View Full-Text
Keywords: glioblastoma multiforme; glutamate receptors; mechanobiology; cell migration; α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA); N-methyl-d-aspartate (NMDA); focal adhesion complex (FAK); protein kinase B (Akt) glioblastoma multiforme; glutamate receptors; mechanobiology; cell migration; α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA); N-methyl-d-aspartate (NMDA); focal adhesion complex (FAK); protein kinase B (Akt)
Show Figures

Graphical abstract

MDPI and ACS Style

Corsi, L.; Mescola, A.; Alessandrini, A. Glutamate Receptors and Glioblastoma Multiforme: An Old “Route” for New Perspectives. Int. J. Mol. Sci. 2019, 20, 1796. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms20071796

AMA Style

Corsi L, Mescola A, Alessandrini A. Glutamate Receptors and Glioblastoma Multiforme: An Old “Route” for New Perspectives. International Journal of Molecular Sciences. 2019; 20(7):1796. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms20071796

Chicago/Turabian Style

Corsi, Lorenzo, Andrea Mescola, and Andrea Alessandrini. 2019. "Glutamate Receptors and Glioblastoma Multiforme: An Old “Route” for New Perspectives" International Journal of Molecular Sciences 20, no. 7: 1796. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms20071796

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop