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Open AccessCommunication

PhSeZnCl in the Synthesis of Steroidal β-Hydroxy-Phenylselenides Having Antibacterial Activity

1
Institute of Chemistry, University of Białystok, ul. Ciołkowskiego 1K, 15-245 Białystok, Poland
2
Department of Microbiological and Nanobiomedical Engineering, Medical University of Białystok, ul. Mickiewicza 2C, 15-222 Bialystok, Poland
3
Group of Catalysis and Organic Green Chemistry–Department of Pharmaceutical Sciences, University of Perugia, Via del Liceo 1, 06132 Perugia, Italy
*
Authors to whom correspondence should be addressed.
Int. J. Mol. Sci. 2019, 20(9), 2121; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms20092121
Received: 1 April 2019 / Revised: 23 April 2019 / Accepted: 24 April 2019 / Published: 29 April 2019
(This article belongs to the Special Issue Redox Modulation: Biological and Therapeutical Implication)
We report here the reaction of in situ prepared PhSeZnCl with steroid derivatives having an epoxide as an electrophilic functionalization. The corresponding ring-opening reaction resulted to be regio- and stereoselective affording to novel phenylselenium-substituted steroids. Assessment of their antibacterial properties against multidrug-resistant bacteria, such as Pseudomonas aeruginosa Xen 5 strain, indicates an interesting bactericidal activity and their ability to prevent bacterial biofilm formation. View Full-Text
Keywords: steroids; selenium; antibacterial; antibiofilm steroids; selenium; antibacterial; antibiofilm
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MDPI and ACS Style

Jastrzebska, I.; Mellea, S.; Salerno, V.; Grzes, P.A.; Siergiejczyk, L.; Niemirowicz-Laskowska, K.; Bucki, R.; Monti, B.; Santi, C. PhSeZnCl in the Synthesis of Steroidal β-Hydroxy-Phenylselenides Having Antibacterial Activity. Int. J. Mol. Sci. 2019, 20, 2121. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms20092121

AMA Style

Jastrzebska I, Mellea S, Salerno V, Grzes PA, Siergiejczyk L, Niemirowicz-Laskowska K, Bucki R, Monti B, Santi C. PhSeZnCl in the Synthesis of Steroidal β-Hydroxy-Phenylselenides Having Antibacterial Activity. International Journal of Molecular Sciences. 2019; 20(9):2121. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms20092121

Chicago/Turabian Style

Jastrzebska, Izabella; Mellea, Stefano; Salerno, Valerio; Grzes, Pawel A.; Siergiejczyk, Leszek; Niemirowicz-Laskowska, Katarzyna; Bucki, Robert; Monti, Bonifacio; Santi, Claudio. 2019. "PhSeZnCl in the Synthesis of Steroidal β-Hydroxy-Phenylselenides Having Antibacterial Activity" Int. J. Mol. Sci. 20, no. 9: 2121. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms20092121

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