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Natural Compounds for Alzheimer’s Disease Therapy: A Systematic Review of Preclinical and Clinical Studies

LEPABE, Department of Chemical Engineering, Faculty of Engineering of the University of Porto, 4200-465 Porto, Portugal
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Int. J. Mol. Sci. 2019, 20(9), 2313; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms20092313
Received: 16 April 2019 / Revised: 4 May 2019 / Accepted: 7 May 2019 / Published: 10 May 2019
(This article belongs to the Special Issue Natural Products and Neuroprotection)
Alzheimer’s Disease (AD) is a neurodegenerative disorder related with the increase of age and it is the main cause of dementia in the world. AD affects cognitive functions, such as memory, with an intensity that leads to several functional losses. The continuous increase of AD incidence demands for an urgent development of effective therapeutic strategies. Despite the extensive research on this disease, only a few drugs able to delay the progression of the disease are currently available. In the last years, several compounds with pharmacological activities isolated from plants, animals and microorganisms, revealed to have beneficial effects for the treatment of AD, targeting different pathological mechanisms. Thus, a wide range of natural compounds may play a relevant role in the prevention of AD and have proven to be efficient in different preclinical and clinical studies. This work aims to review the natural compounds that until this date were described as having significant benefits for this neurological disease, focusing on studies that present clinical trials. View Full-Text
Keywords: neurodegenerative disease; bioactive compound; natural extract; β-amyloid peptide; tau protein; clinical trial; human studies; animal studies; in vitro studies neurodegenerative disease; bioactive compound; natural extract; β-amyloid peptide; tau protein; clinical trial; human studies; animal studies; in vitro studies
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MDPI and ACS Style

Andrade, S.; Ramalho, M.J.; Loureiro, J.A.; Pereira, M.d.C. Natural Compounds for Alzheimer’s Disease Therapy: A Systematic Review of Preclinical and Clinical Studies. Int. J. Mol. Sci. 2019, 20, 2313. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms20092313

AMA Style

Andrade S, Ramalho MJ, Loureiro JA, Pereira MdC. Natural Compounds for Alzheimer’s Disease Therapy: A Systematic Review of Preclinical and Clinical Studies. International Journal of Molecular Sciences. 2019; 20(9):2313. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms20092313

Chicago/Turabian Style

Andrade, Stephanie; Ramalho, Maria J.; Loureiro, Joana A.; Pereira, Maria d.C. 2019. "Natural Compounds for Alzheimer’s Disease Therapy: A Systematic Review of Preclinical and Clinical Studies" Int. J. Mol. Sci. 20, no. 9: 2313. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms20092313

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Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

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