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Stereocilia Rootlets: Actin-Based Structures That Are Essential for Structural Stability of the Hair Bundle

Oregon Hearing Research Center & Vollum Institute, Oregon Health & Science University, Portland, OR 97239, USA
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Int. J. Mol. Sci. 2020, 21(1), 324; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21010324
Received: 12 December 2019 / Revised: 30 December 2019 / Accepted: 1 January 2020 / Published: 3 January 2020
(This article belongs to the Special Issue Frontiers in the Actin Cytoskeleton)
Sensory hair cells of the inner ear rely on the hair bundle, a cluster of actin-filled stereocilia, to transduce auditory and vestibular stimuli into electrical impulses. Because they are long and thin projections, stereocilia are most prone to damage at the point where they insert into the hair cell’s soma. Moreover, this is the site of stereocilia pivoting, the mechanical movement that induces transduction, which additionally weakens this area mechanically. To bolster this fragile area, hair cells construct a dense core called the rootlet at the base of each stereocilium, which extends down into the actin meshwork of the cuticular plate and firmly anchors the stereocilium. Rootlets are constructed with tightly packed actin filaments that extend from stereocilia actin filaments which are wrapped with TRIOBP; in addition, many other proteins contribute to the rootlet and its associated structures. Rootlets allow stereocilia to sustain innumerable deflections over their lifetimes and exemplify the unique manner in which sensory hair cells exploit actin and its associated proteins to carry out the function of mechanotransduction. View Full-Text
Keywords: rootlet; actin; stereocilia; hair cell rootlet; actin; stereocilia; hair cell
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MDPI and ACS Style

Pacentine, I.; Chatterjee, P.; Barr-Gillespie, P.G. Stereocilia Rootlets: Actin-Based Structures That Are Essential for Structural Stability of the Hair Bundle. Int. J. Mol. Sci. 2020, 21, 324. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21010324

AMA Style

Pacentine I, Chatterjee P, Barr-Gillespie PG. Stereocilia Rootlets: Actin-Based Structures That Are Essential for Structural Stability of the Hair Bundle. International Journal of Molecular Sciences. 2020; 21(1):324. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21010324

Chicago/Turabian Style

Pacentine, Itallia, Paroma Chatterjee, and Peter G. Barr-Gillespie 2020. "Stereocilia Rootlets: Actin-Based Structures That Are Essential for Structural Stability of the Hair Bundle" International Journal of Molecular Sciences 21, no. 1: 324. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21010324

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