Next Article in Journal
Inhibition of FGFR2-Signaling Attenuates a Homology-Mediated DNA Repair in GIST and Sensitizes Them to DNA-Topoisomerase II Inhibitors
Previous Article in Journal
Codon Directional Asymmetry Suggests Swapped Prebiotic 1st and 2nd Codon Positions
Review

Senile Osteoporosis: The Involvement of Differentiation and Senescence of Bone Marrow Stromal Cells

by 1,2,3, 1,2,3, 1,2,3, 1,2,3, 1,2,3,* and 1,2,3,*
1
Laboratory for Bone Metabolism, Key Laboratory for Space Biosciences and Biotechnology, School of Life Sciences, Northwestern Polytechnical University, Xi’an 710072, China
2
Research Center for Special Medicine and Health Systems Engineering, School of Life Sciences, Northwestern Polytechnical University, Xi’an 710072, China
3
NPU-UAB Joint Laboratory for Bone Metabolism, School of Life Sciences, Northwestern Polytechnical University, Xi’an 710072, China
*
Authors to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(1), 349; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21010349
Received: 13 December 2019 / Revised: 26 December 2019 / Accepted: 31 December 2019 / Published: 5 January 2020
(This article belongs to the Section Biochemistry)
Senile osteoporosis has become a worldwide bone disease with the aging of the world population. It increases the risk of bone fracture and seriously affects human health. Unlike postmenopausal osteoporosis which is linked to menopause in women, senile osteoporosis is due to aging, hence, affecting both men and women. It is commonly found in people with more than their 70s. Evidence has shown that with age increase, bone marrow stromal cells (BMSCs) differentiate into more adipocytes rather than osteoblasts and undergo senescence, which leads to decreased bone formation and contributes to senile osteoporosis. Therefore, it is necessary to uncover the molecular mechanisms underlying the functional changes of BMSCs. It will benefit not only for understanding the senile osteoporosis development, but also for finding new therapies to treat senile osteoporosis. Here, we review the recent advances of the functional alterations of BMSCs and the related mechanisms during senile osteoporosis development. Moreover, the treatment of senile osteoporosis by aiming at BMSCs is introduced. View Full-Text
Keywords: senile osteoporosis; bone marrow stromal cells; differentiation; senescence; treatment senile osteoporosis; bone marrow stromal cells; differentiation; senescence; treatment
Show Figures

Figure 1

MDPI and ACS Style

Qadir, A.; Liang, S.; Wu, Z.; Chen, Z.; Hu, L.; Qian, A. Senile Osteoporosis: The Involvement of Differentiation and Senescence of Bone Marrow Stromal Cells. Int. J. Mol. Sci. 2020, 21, 349. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21010349

AMA Style

Qadir A, Liang S, Wu Z, Chen Z, Hu L, Qian A. Senile Osteoporosis: The Involvement of Differentiation and Senescence of Bone Marrow Stromal Cells. International Journal of Molecular Sciences. 2020; 21(1):349. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21010349

Chicago/Turabian Style

Qadir, Abdul, Shujing Liang, Zixiang Wu, Zhihao Chen, Lifang Hu, and Airong Qian. 2020. "Senile Osteoporosis: The Involvement of Differentiation and Senescence of Bone Marrow Stromal Cells" International Journal of Molecular Sciences 21, no. 1: 349. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21010349

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop