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Oxidative Stress-Responsive MicroRNAs in Heart Injury

Centre of Experimental Medicine, Institute for Heart Research, Slovak Academy of Sciences, 841 04 Bratislava, Slovakia
Department of Animal Physiology and Ethology, Faculty of Natural Sciences, Comenius University, 842 15 Bratislava, Slovakia
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(1), 358;
Received: 30 October 2019 / Revised: 31 December 2019 / Accepted: 3 January 2020 / Published: 5 January 2020
Reactive oxygen species (ROS) are important molecules in the living organisms as a part of many signaling pathways. However, if overproduced, they also play a significant role in the development of cardiovascular diseases, such as arrhythmia, cardiomyopathy, ischemia/reperfusion injury (e.g., myocardial infarction and heart transplantation), and heart failure. As a result of oxidative stress action, apoptosis, hypertrophy, and fibrosis may occur. MicroRNAs (miRNAs) represent important endogenous nucleotides that regulate many biological processes, including those involved in heart damage caused by oxidative stress. Oxidative stress can alter the expression level of many miRNAs. These changes in miRNA expression occur mainly via modulation of nuclear factor erythroid 2-related factor 2 (Nrf2), sirtuins, calcineurin/nuclear factor of activated T cell (NFAT), or nuclear factor kappa B (NF-κB) pathways. Up until now, several circulating miRNAs have been reported to be potential biomarkers of ROS-related cardiac diseases, including myocardial infarction, hypertrophy, ischemia/reperfusion, and heart failure, such as miRNA-499, miRNA-199, miRNA-21, miRNA-144, miRNA-208a, miRNA-34a, etc. On the other hand, a lot of studies are aimed at using miRNAs for therapeutic purposes. This review points to the need for studying the role of redox-sensitive miRNAs, to identify more effective biomarkers and develop better therapeutic targets for oxidative-stress-related heart diseases. View Full-Text
Keywords: cardiovascular diseases; ischemia/reperfusion injury; miRNA; oxidative stress; transplantation cardiovascular diseases; ischemia/reperfusion injury; miRNA; oxidative stress; transplantation
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MDPI and ACS Style

Kura, B.; Szeiffova Bacova, B.; Kalocayova, B.; Sykora, M.; Slezak, J. Oxidative Stress-Responsive MicroRNAs in Heart Injury. Int. J. Mol. Sci. 2020, 21, 358.

AMA Style

Kura B, Szeiffova Bacova B, Kalocayova B, Sykora M, Slezak J. Oxidative Stress-Responsive MicroRNAs in Heart Injury. International Journal of Molecular Sciences. 2020; 21(1):358.

Chicago/Turabian Style

Kura, Branislav, Barbara Szeiffova Bacova, Barbora Kalocayova, Matus Sykora, and Jan Slezak. 2020. "Oxidative Stress-Responsive MicroRNAs in Heart Injury" International Journal of Molecular Sciences 21, no. 1: 358.

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