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Nutrients and Porphyria: An Intriguing Crosstalk

Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, UOC General Medicine, via F. Sforza 35, 20122 Milan, Italy
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Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Int. J. Mol. Sci. 2020, 21(10), 3462; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21103462
Received: 17 April 2020 / Revised: 8 May 2020 / Accepted: 11 May 2020 / Published: 14 May 2020
(This article belongs to the Special Issue Nutrigenomics in Liver Diseases: An Uncharted Territory)
Porphyria refers to a group of fascinating diseases from a metabolic and nutritional standpoint as it provides an example of how metabolic manipulation can be used for therapeutic purposes. It is characterized by defects in heme synthesis, particularly in the erythrocytes and liver. Specific enzymes involved in heme biosynthesis directly depend on adequate levels of vitamins and minerals in the tissues. Moreover, micronutrients that are required for producing succinyl CoA and other intermediates in the Krebs (TCA) cycle are indirectly necessary for heme metabolism. This review summarizes articles that describe the nutritional status, supplements intake, and dietary practices of patients affected by porphyria, paying special attention to the therapeutic use of nutrients that may help or hinder this group of diseases. View Full-Text
Keywords: porphyria; nutrients; nutrigenomics; lipid and glucose metabolism; genetic factors; diet; personalized nutrition; iron metabolism porphyria; nutrients; nutrigenomics; lipid and glucose metabolism; genetic factors; diet; personalized nutrition; iron metabolism
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MDPI and ACS Style

Di Pierro, E.; Granata, F. Nutrients and Porphyria: An Intriguing Crosstalk. Int. J. Mol. Sci. 2020, 21, 3462. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21103462

AMA Style

Di Pierro E, Granata F. Nutrients and Porphyria: An Intriguing Crosstalk. International Journal of Molecular Sciences. 2020; 21(10):3462. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21103462

Chicago/Turabian Style

Di Pierro, Elena, and Francesca Granata. 2020. "Nutrients and Porphyria: An Intriguing Crosstalk" International Journal of Molecular Sciences 21, no. 10: 3462. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21103462

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