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Review

Animal Models to Translate Phage Therapy to Human Medicine

1
Dipartimento di Biotecnologie Mediche e Medicina Traslazionale, Università degli Studi di Milano, LITA, Via Fratelli Cervi 93, Segrate, 20090 Milano, Italy
2
Dipartimento di Scienze Cliniche e Comunità, Università degli Studi di Milano, Via San Barnaba 8, 20122 Milano, Italy
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(10), 3715; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21103715
Received: 13 April 2020 / Revised: 21 May 2020 / Accepted: 22 May 2020 / Published: 25 May 2020
(This article belongs to the Section Molecular Microbiology)
Phagotherapy, the use of bacteriophages to fight bacterial infections as an alternative to antibiotic treatments, has become of increasing interest in the last years. This is mainly due to the diffusion of multi-drug resistant (MDR) bacterial infections that constitute a serious issue for public health. Phage therapy is gaining favor due to its success in agriculture and veterinary treatments and its extensive utilization for human therapeutic protocols in the Eastern world. In the last decades, some clinical trials and compassionate treatments have also been performed in the Western world, indicating that phage therapy is getting closer to its introduction in standard therapy protocols. However, several questions concerning the use of phages in human therapeutic treatments are still present and need to be addressed. In this review, we illustrate the state of art of phage therapy and examine the role of animal models to translate these treatments to humans. View Full-Text
Keywords: phage therapy; bacteria; animal models; immune system; antibiotics phage therapy; bacteria; animal models; immune system; antibiotics
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MDPI and ACS Style

Brix, A.; Cafora, M.; Aureli, M.; Pistocchi, A. Animal Models to Translate Phage Therapy to Human Medicine. Int. J. Mol. Sci. 2020, 21, 3715. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21103715

AMA Style

Brix A, Cafora M, Aureli M, Pistocchi A. Animal Models to Translate Phage Therapy to Human Medicine. International Journal of Molecular Sciences. 2020; 21(10):3715. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21103715

Chicago/Turabian Style

Brix, Alessia, Marco Cafora, Massimo Aureli, and Anna Pistocchi. 2020. "Animal Models to Translate Phage Therapy to Human Medicine" International Journal of Molecular Sciences 21, no. 10: 3715. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21103715

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