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Article

Recovery of BDNF and CB1R in the Prefrontal Cortex Underlying Improvement of Working Memory in Prenatal DEHP-Exposed Male Rats after Aerobic Exercise

1
Department of Sports Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan
2
Department of Medical Research, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(11), 3867; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21113867
Received: 30 April 2020 / Revised: 21 May 2020 / Accepted: 28 May 2020 / Published: 29 May 2020
(This article belongs to the Special Issue Effects of Hormones on the Nervous System and Behavior)
Early-life exposure to di-(2-ethylhexyl)-phthalate (DEHP) has been suggested to relate to hyperactivity, lack of attention, and working memory deficits in school-age children. Brain-derived neurotrophic factor (BDNF) and endocannabinoids are induced by aerobic exercises to provide beneficial effects on brain functions. This study investigated the mechanisms underlying working memory impairment and the protective role of exercise in prenatal DEHP-exposed male rats. Sprague Dawley dams were fed with vehicle or DEHP during gestation. The male offspring were trained to exercise on a treadmill for 5 weeks, which was followed by an assessment of their working memory with a T-maze delayed non-match-to-sample task. The expressions of BDNF, dopamine D1 receptor (D1R), cannabinoid receptor 1 (CB1R), and fatty acid amide hydrolase (FAAH) in the prefrontal cortex were detected by Western blot. The results showed that DEHP-exposed rats exhibited working memory impairments without significant alterations in locomotor activities. The reduced expressions of prefrontal BDNF and CB1R were obtained in the DEHP-exposed rats, while D1R and FAAH were barely affected. Importantly, aerobic exercise during childhood-adolescence prevented the impairment of working memory in the DEHP-exposed rats by recovering the BDNF and CB1R expressions in the prefrontal cortex. These findings suggest that exercise may provide beneficial effects in ameliorating the impairment of working memory in the prenatal DEHP-exposed male rats at late adolescence. View Full-Text
Keywords: di-(2-ethylhexyl)-phthalate; working memory; brain-derived neurotrophic factor; endocannabinoids; aerobic exercise di-(2-ethylhexyl)-phthalate; working memory; brain-derived neurotrophic factor; endocannabinoids; aerobic exercise
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MDPI and ACS Style

Wang, D.-C.; Lin, H.-T.; Lee, Y.-J.; Yu, H.-F.; Wu, S.-R.; Qamar, M.U. Recovery of BDNF and CB1R in the Prefrontal Cortex Underlying Improvement of Working Memory in Prenatal DEHP-Exposed Male Rats after Aerobic Exercise. Int. J. Mol. Sci. 2020, 21, 3867. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21113867

AMA Style

Wang D-C, Lin H-T, Lee Y-J, Yu H-F, Wu S-R, Qamar MU. Recovery of BDNF and CB1R in the Prefrontal Cortex Underlying Improvement of Working Memory in Prenatal DEHP-Exposed Male Rats after Aerobic Exercise. International Journal of Molecular Sciences. 2020; 21(11):3867. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21113867

Chicago/Turabian Style

Wang, Dean-Chuan; Lin, Hwai-Ting; Lee, Yi-Ju; Yu, Hsien-Fu; Wu, Sin-Ru; Qamar, Muhammad U. 2020. "Recovery of BDNF and CB1R in the Prefrontal Cortex Underlying Improvement of Working Memory in Prenatal DEHP-Exposed Male Rats after Aerobic Exercise" Int. J. Mol. Sci. 21, no. 11: 3867. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21113867

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