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Review

Arabidopsis Transmembrane Receptor-Like Kinases (RLKs): A Bridge between Extracellular Signal and Intracellular Regulatory Machinery

Department of Biology, Indian Institute of Science Education and Research (IISER) Tirupati, Tirupati, Andhra Pradesh 517507, India
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Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Int. J. Mol. Sci. 2020, 21(11), 4000; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21114000
Received: 16 May 2020 / Revised: 31 May 2020 / Accepted: 1 June 2020 / Published: 3 June 2020
(This article belongs to the Special Issue Cell Signaling in Model Plants)
Receptors form the crux for any biochemical signaling. Receptor-like kinases (RLKs) are conserved protein kinases in eukaryotes that establish signaling circuits to transduce information from outer plant cell membrane to the nucleus of plant cells, eventually activating processes directing growth, development, stress responses, and disease resistance. Plant RLKs share considerable homology with the receptor tyrosine kinases (RTKs) of the animal system, differing at the site of phosphorylation. Typically, RLKs have a membrane-localization signal in the amino-terminal, followed by an extracellular ligand-binding domain, a solitary membrane-spanning domain, and a cytoplasmic kinase domain. The functional characterization of ligand-binding domains of the various RLKs has demonstrated their essential role in the perception of extracellular stimuli, while its cytosolic kinase domain is usually confined to the phosphorylation of their substrates to control downstream regulatory machinery. Identification of the several ligands of RLKs, as well as a few of its immediate substrates have predominantly contributed to a better understanding of the fundamental signaling mechanisms. In the model plant Arabidopsis, several studies have indicated that multiple RLKs are involved in modulating various types of physiological roles via diverse signaling routes. Here, we summarize recent advances and provide an updated overview of transmembrane RLKs in Arabidopsis. View Full-Text
Keywords: Arabidopsis; development; kinase; receptor; stress Arabidopsis; development; kinase; receptor; stress
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MDPI and ACS Style

Jose, J.; Ghantasala, S.; Roy Choudhury, S. Arabidopsis Transmembrane Receptor-Like Kinases (RLKs): A Bridge between Extracellular Signal and Intracellular Regulatory Machinery. Int. J. Mol. Sci. 2020, 21, 4000. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21114000

AMA Style

Jose J, Ghantasala S, Roy Choudhury S. Arabidopsis Transmembrane Receptor-Like Kinases (RLKs): A Bridge between Extracellular Signal and Intracellular Regulatory Machinery. International Journal of Molecular Sciences. 2020; 21(11):4000. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21114000

Chicago/Turabian Style

Jose, Jismon, Swathi Ghantasala, and Swarup Roy Choudhury. 2020. "Arabidopsis Transmembrane Receptor-Like Kinases (RLKs): A Bridge between Extracellular Signal and Intracellular Regulatory Machinery" International Journal of Molecular Sciences 21, no. 11: 4000. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21114000

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