Next Article in Journal
Molecular Epidemiology of B3 and D8 Measles Viruses through Hemagglutinin Phylogenetic History
Next Article in Special Issue
Sodium Intake and Chronic Kidney Disease
Previous Article in Journal
Role of Dendritic Cells in Inflammation
Previous Article in Special Issue
Na+-Coupled Nutrient Cotransport Induced Luminal Negative Potential and Claudin-15 Play an Important Role in Paracellular Na+ Recycling in Mouse Small Intestine
Article

PGI2 Analog Attenuates Salt-Induced Renal Injury through the Inhibition of Inflammation and Rac1-MR Activation

1
Division of Clinical Epigenetics, Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo 153-8904, Japan
2
Division of Nephrology, Department of Internal Medicine, Teikyo University School of Medicine, Tokyo 173-8606, Japan
3
Department of Internal Medicine, International University of Health and Welfare Mita Hospital, Tokyo 108-8329, Japan
4
Center for Basic Medical Research at Narita Campus, International University of Health and Welfare, Chiba 286-8686, Japan
5
Shinshu University School of Medicine and Research Center for Social Systems, Nagano 389-0111, Japan
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(12), 4433; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21124433
Received: 1 June 2020 / Revised: 18 June 2020 / Accepted: 18 June 2020 / Published: 22 June 2020
(This article belongs to the Special Issue Sodium Intake and Related Diseases)
Renal inflammation is known to be involved in salt-induced renal damage, leading to end-stage renal disease. This study aims to evaluate the role of inflammation in anti-inflammatory and renoprotective effects of beraprost sodium (BPS), a prostaglandin I2 (PGI2) analog, in Dahl salt-sensitive (DS) rats. Five-week-old male DS rats were fed a normal-salt diet (0.5% NaCl), a high-salt diet (8% NaCl), or a high-salt diet plus BPS treatment for 3 weeks. BPS treatment could inhibit marked proteinuria and renal injury in salt-loaded DS rats with elevated blood pressure, accompanied by renal inflammation suppression. Notably, high salt increased renal expression of active Rac1, followed by increased Sgk1 expressions, a downstream molecule of mineralocorticoid receptor (MR) signal, indicating salt-induced activation of Rac1-MR pathway. However, BPS administration inhibited salt-induced Rac1-MR activation as well as renal inflammation and damage, suggesting that Rac1-MR pathway is involved in anti-inflammatory and renoprotective effects of PGI2. Based upon Rac1 activated by inflammation, moreover, BPS inhibited salt-induced activation of Rac1-MR pathway by renal inflammation suppression, resulting in the attenuation of renal damage in salt-loaded DS rats. Thus, BPS is efficacious for the treatment of salt-induced renal injury. View Full-Text
Keywords: blood pressure; inflammation; mineralocorticoid receptor; Rac1; renal injury; salt-sensitive hypertension blood pressure; inflammation; mineralocorticoid receptor; Rac1; renal injury; salt-sensitive hypertension
Show Figures

Figure 1

MDPI and ACS Style

Hirohama, D.; Kawarazaki, W.; Nishimoto, M.; Ayuzawa, N.; Marumo, T.; Shibata, S.; Fujita, T. PGI2 Analog Attenuates Salt-Induced Renal Injury through the Inhibition of Inflammation and Rac1-MR Activation. Int. J. Mol. Sci. 2020, 21, 4433. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21124433

AMA Style

Hirohama D, Kawarazaki W, Nishimoto M, Ayuzawa N, Marumo T, Shibata S, Fujita T. PGI2 Analog Attenuates Salt-Induced Renal Injury through the Inhibition of Inflammation and Rac1-MR Activation. International Journal of Molecular Sciences. 2020; 21(12):4433. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21124433

Chicago/Turabian Style

Hirohama, Daigoro, Wakako Kawarazaki, Mitsuhiro Nishimoto, Nobuhiro Ayuzawa, Takeshi Marumo, Shigeru Shibata, and Toshiro Fujita. 2020. "PGI2 Analog Attenuates Salt-Induced Renal Injury through the Inhibition of Inflammation and Rac1-MR Activation" International Journal of Molecular Sciences 21, no. 12: 4433. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21124433

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop