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Review

Understanding the Biology of Human Interstitial Cells of Cajal in Gastrointestinal Motility

1
School of Medicine, Western Sydney University, Campbelltown, NSW 2560, Australia
2
Campbelltown Private Hospital, Campbelltown, NSW 2560, Australia
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(12), 4540; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21124540
Received: 3 June 2020 / Revised: 19 June 2020 / Accepted: 23 June 2020 / Published: 25 June 2020
(This article belongs to the Special Issue Telocytes and Other Interstitial Cells: From Structure to Function)
Millions of patients worldwide suffer from gastrointestinal (GI) motility disorders such as gastroparesis. These disorders typically include debilitating symptoms, such as chronic nausea and vomiting. As no cures are currently available, clinical care is limited to symptom management, while the underlying causes of impaired GI motility remain unaddressed. The efficient movement of contents through the GI tract is facilitated by peristalsis. These rhythmic slow waves of GI muscle contraction are mediated by several cell types, including smooth muscle cells, enteric neurons, telocytes, and specialised gut pacemaker cells called interstitial cells of Cajal (ICC). As ICC dysfunction or loss has been implicated in several GI motility disorders, ICC represent a potentially valuable therapeutic target. Due to their availability, murine ICC have been extensively studied at the molecular level using both normal and diseased GI tissue. In contrast, relatively little is known about the biology of human ICC or their involvement in GI disease pathogenesis. Here, we demonstrate human gastric tissue as a source of primary human cells with ICC phenotype. Further characterisation of these cells will provide new insights into human GI biology, with the potential for developing novel therapies to address the fundamental causes of GI dysmotility. View Full-Text
Keywords: gastrointestinal motility; peristalsis; interstitial cells of Cajal; ICC; molecular characterisation; bioinformatics; mouse; human; pluripotent stem cells. gastrointestinal motility; peristalsis; interstitial cells of Cajal; ICC; molecular characterisation; bioinformatics; mouse; human; pluripotent stem cells.
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MDPI and ACS Style

Foong, D.; Zhou, J.; Zarrouk, A.; Ho, V.; O’Connor, M.D. Understanding the Biology of Human Interstitial Cells of Cajal in Gastrointestinal Motility. Int. J. Mol. Sci. 2020, 21, 4540. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21124540

AMA Style

Foong D, Zhou J, Zarrouk A, Ho V, O’Connor MD. Understanding the Biology of Human Interstitial Cells of Cajal in Gastrointestinal Motility. International Journal of Molecular Sciences. 2020; 21(12):4540. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21124540

Chicago/Turabian Style

Foong, Daphne, Jerry Zhou, Ali Zarrouk, Vincent Ho, and Michael D. O’Connor 2020. "Understanding the Biology of Human Interstitial Cells of Cajal in Gastrointestinal Motility" International Journal of Molecular Sciences 21, no. 12: 4540. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21124540

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