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Article

The Influence of Bisphenol a on the Nitrergic Nervous Structures in the Domestic Porcine Uterus

1
Department of Internal Disease with Clinic, Faculty of Veterinary Medicine, University of Warmia and Mazury, Street Oczapowskiego 14, 10-719 Olsztyn, Poland
2
Department of Clinical Physiology, Faculty of Veterinary Medicine, University of Warmia and Mazury, Street Oczapowskiego 14, 10-719 Olsztyn, Poland
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(12), 4543; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21124543
Received: 7 June 2020 / Revised: 22 June 2020 / Accepted: 23 June 2020 / Published: 26 June 2020
(This article belongs to the Special Issue Nitric Oxide: Physiology, Pharmacology, and Therapeutic Applications)
Bisphenol A (BPA) is one of the most common environmental pollutants among endocrine disruptors. Due to its similarity to estrogen, BPA may affect estrogen receptors and show adverse effects on many internal organs. The reproductive system is particularly vulnerable to the impact of BPA, but knowledge about BPA-induced changes in the innervation of the uterus is relatively scarce. Therefore, this study aimed to investigate the influence of various doses of BPA on nitrergic nerves supplying the uterus with the double immunofluorescence method. It has been shown that even low doses of BPA caused an increase in the number of nitrergic nerves in the uterine wall and changed their neurochemical characterization. During the present study, changes in the number of nitrergic nerves simultaneously immunoreactive to substance P, vasoactive intestinal polypeptide, pituitary adenylate cyclase-activating peptide, and/or cocaine- and amphetamine-regulated transcript were found under the influence of BPA. The obtained results strongly suggest that nitrergic nerves in the uterine wall participate in adaptive and/or protective processes aimed at homeostasis maintenance in the uterine activity under the impact of BPA. View Full-Text
Keywords: bisphenol A; nitric oxide; innervation; neuropeptides; uterus bisphenol A; nitric oxide; innervation; neuropeptides; uterus
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MDPI and ACS Style

Rytel, L.; Gonkowski, S. The Influence of Bisphenol a on the Nitrergic Nervous Structures in the Domestic Porcine Uterus. Int. J. Mol. Sci. 2020, 21, 4543. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21124543

AMA Style

Rytel L, Gonkowski S. The Influence of Bisphenol a on the Nitrergic Nervous Structures in the Domestic Porcine Uterus. International Journal of Molecular Sciences. 2020; 21(12):4543. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21124543

Chicago/Turabian Style

Rytel, Liliana, and Slawomir Gonkowski. 2020. "The Influence of Bisphenol a on the Nitrergic Nervous Structures in the Domestic Porcine Uterus" International Journal of Molecular Sciences 21, no. 12: 4543. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21124543

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