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Review

EPAC in Vascular Smooth Muscle Cells

1
Department of Biology, American University of Beirut, P.O. Box 11-0236, Beirut, Lebanon
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Department of Pharmacology and Therapeutics, Beirut Arab University, P.O. Box 11-5020, Beirut, Lebanon
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Department of Biology, United Arab Emirates University, P.O. Box 15551, Al-Ain, UAE
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Department of Clinical and Experimental Medicine, University of Messina, 98125 Messina, Italy
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Department of Pharmacology and Toxicology, American University of Beirut, P.O. Box 11-0236, Beirut, Lebanon
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Department of Pharmacology and Toxicology, Alexandria University, 21526 Alexandria, Egypt
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Department of Nutrition, University of Petra, P.O. Box 961343, Amman 11196, Jordan
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Department of Biochemistry and Molecular Genetics, American University of Beirut, P.O. Box 11-0236, Beirut, Lebanon
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Department of Biomedical Sciences, Qatar University, P.O. Box 2713, Doha, Qatar
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(14), 5160; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21145160
Received: 17 June 2020 / Revised: 9 July 2020 / Accepted: 19 July 2020 / Published: 21 July 2020
Vascular smooth muscle cells (VSMCs) are major components of blood vessels. They regulate physiological functions, such as vascular tone and blood flow. Under pathological conditions, VSMCs undergo a remodeling process known as phenotypic switching. During this process, VSMCs lose their contractility and acquire a synthetic phenotype, where they over-proliferate and migrate from the tunica media to the tunica interna, contributing to the occlusion of blood vessels. Since their discovery as effector proteins of cyclic adenosine 3′,5′-monophosphate (cAMP), exchange proteins activated by cAMP (EPACs) have been shown to play vital roles in a plethora of pathways in different cell systems. While extensive research to identify the role of EPAC in the vasculature has been conducted, much remains to be explored to resolve the reported discordance in EPAC’s effects. In this paper, we review the role of EPAC in VSMCs, namely its regulation of the vascular tone and phenotypic switching, with the likely involvement of reactive oxygen species (ROS) in the interplay between EPAC and its targets/effectors. View Full-Text
Keywords: EPAC; vascular smooth muscle cells; ROS; cAMP; phenotypic switch; cardiovascular disease EPAC; vascular smooth muscle cells; ROS; cAMP; phenotypic switch; cardiovascular disease
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MDPI and ACS Style

Wehbe, N.; Nasser, S.A.; Al-Dhaheri, Y.; Iratni, R.; Bitto, A.; El-Yazbi, A.F.; Badran, A.; Kobeissy, F.; Baydoun, E.; Eid, A.H. EPAC in Vascular Smooth Muscle Cells. Int. J. Mol. Sci. 2020, 21, 5160. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21145160

AMA Style

Wehbe N, Nasser SA, Al-Dhaheri Y, Iratni R, Bitto A, El-Yazbi AF, Badran A, Kobeissy F, Baydoun E, Eid AH. EPAC in Vascular Smooth Muscle Cells. International Journal of Molecular Sciences. 2020; 21(14):5160. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21145160

Chicago/Turabian Style

Wehbe, Nadine, Suzanne A. Nasser, Yusra Al-Dhaheri, Rabah Iratni, Alessandra Bitto, Ahmed F. El-Yazbi, Adnan Badran, Firas Kobeissy, Elias Baydoun, and Ali H. Eid 2020. "EPAC in Vascular Smooth Muscle Cells" International Journal of Molecular Sciences 21, no. 14: 5160. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21145160

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