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Regulating Divergent Transcriptomes through mRNA Splicing and Its Modulation Using Various Small Compounds
Review

Intrinsic Regulatory Role of RNA Structural Arrangement in Alternative Splicing Control

Department of Gene Expression, Institute of Molecular Biology and Biotechnology, Faculty of Biology, Adam Mickiewicz University, 61-614 Poznan, Poland
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Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(14), 5161; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21145161
Received: 1 July 2020 / Accepted: 17 July 2020 / Published: 21 July 2020
Alternative splicing is a highly sophisticated process, playing a significant role in posttranscriptional gene expression and underlying the diversity and complexity of organisms. Its regulation is multilayered, including an intrinsic role of RNA structural arrangement which undergoes time- and tissue-specific alterations. In this review, we describe the principles of RNA structural arrangement and briefly decipher its cis- and trans-acting cellular modulators which serve as crucial determinants of biological functionality of the RNA structure. Subsequently, we engage in a discussion about the RNA structure-mediated mechanisms of alternative splicing regulation. On one hand, the impairment of formation of optimal RNA structures may have critical consequences for the splicing outcome and further contribute to understanding the pathomechanism of severe disorders. On the other hand, the structural aspects of RNA became significant features taken into consideration in the endeavor of finding potential therapeutic treatments. Both aspects have been addressed by us emphasizing the importance of ongoing studies in both fields. View Full-Text
Keywords: RNA structural arrangement; alternative splicing; RNA structure modulators; RNA structure- and splicing-associated diseases RNA structural arrangement; alternative splicing; RNA structure modulators; RNA structure- and splicing-associated diseases
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MDPI and ACS Style

Taylor, K.; Sobczak, K. Intrinsic Regulatory Role of RNA Structural Arrangement in Alternative Splicing Control. Int. J. Mol. Sci. 2020, 21, 5161. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21145161

AMA Style

Taylor K, Sobczak K. Intrinsic Regulatory Role of RNA Structural Arrangement in Alternative Splicing Control. International Journal of Molecular Sciences. 2020; 21(14):5161. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21145161

Chicago/Turabian Style

Taylor, Katarzyna, and Krzysztof Sobczak. 2020. "Intrinsic Regulatory Role of RNA Structural Arrangement in Alternative Splicing Control" International Journal of Molecular Sciences 21, no. 14: 5161. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21145161

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