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Therapeutic Potentials of Extracellular Vesicles for the Treatment of Diabetes and Diabetic Complications

by 1,2,†, 1,†, 1, 2 and 1,*
1
Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, NJ 07110, USA
2
Department of Chemistry and Chemistry Biology, Stevens Institute of Technology, Hoboken, NJ 07030, USA
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Int. J. Mol. Sci. 2020, 21(14), 5163; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21145163
Received: 23 June 2020 / Revised: 13 July 2020 / Accepted: 16 July 2020 / Published: 21 July 2020
(This article belongs to the Special Issue Extracellular Vesicles in Inflammation)
Extracellular vesicles (EVs), including exosomes and microvesicles, are nano-to-micrometer vesicles released from nearly all cellular types. EVs comprise a mixture of bioactive molecules (e.g., mRNAs, miRNAs, lipids, and proteins) that can be transported to the targeted cells/tissues via the blood or lymph circulation. Recently, EVs have received increased attention, owing to their emerging roles in cell-to-cell communication, or as biomarkers with the therapeutic potential to replace cell-based therapy. Diabetes comprises a group of metabolic disorders characterized by hyperglycemia that cause the development of life-threatening complications. The impacts of conventional clinical treatment are generally limited and are followed by many side effects, including hypoglycemia, obesity, and damage to the liver and kidney. Recently, several studies have shown that EVs released by stem cells and immune cells can regulate gene expression in the recipient cells, thus providing a strategy to treat diabetes and its complications. In this review, we summarize the results from currently available studies, demonstrating the therapeutic potentials of EVs in diabetes and diabetic complications. Additionally, we highlight recommendations for future research. View Full-Text
Keywords: extracellular vesicle; exosomes; isolation; cell-to-cell communication; biomarker; diabetes; diabetic complication extracellular vesicle; exosomes; isolation; cell-to-cell communication; biomarker; diabetes; diabetic complication
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MDPI and ACS Style

Hu, W.; Song, X.; Yu, H.; Sun, J.; Zhao, Y. Therapeutic Potentials of Extracellular Vesicles for the Treatment of Diabetes and Diabetic Complications. Int. J. Mol. Sci. 2020, 21, 5163. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21145163

AMA Style

Hu W, Song X, Yu H, Sun J, Zhao Y. Therapeutic Potentials of Extracellular Vesicles for the Treatment of Diabetes and Diabetic Complications. International Journal of Molecular Sciences. 2020; 21(14):5163. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21145163

Chicago/Turabian Style

Hu, Wei, Xiang Song, Haibo Yu, Jingyu Sun, and Yong Zhao. 2020. "Therapeutic Potentials of Extracellular Vesicles for the Treatment of Diabetes and Diabetic Complications" International Journal of Molecular Sciences 21, no. 14: 5163. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21145163

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