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Review

Early Life Oxidative Stress and Long-Lasting Cardiovascular Effects on Offspring Conceived by Assisted Reproductive Technologies: A Review

1
Department of Obstetrics and Gynecology, University Hospital, LMU Munich, 81377 Munich, Germany
2
Department of Obstetrics and Gynecology, University Hospital Augsburg, 86156 Augsburg, Germany
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(15), 5175; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21155175
Received: 29 June 2020 / Revised: 18 July 2020 / Accepted: 20 July 2020 / Published: 22 July 2020
(This article belongs to the Special Issue Reproductive Immunology: Cellular and Molecular Biology 2.0)
Assisted reproductive technology (ART) has rapidly developed and is now widely practised worldwide. Both the characteristics of ART (handling gametes/embryos in vitro) and the infertility backgrounds of ART parents (such as infertility diseases and unfavourable lifestyles or diets) could cause increased oxidative stress (OS) that may exert adverse influences on gametogenesis, fertilisation, and foetation, even causing a long-lasting influence on the offspring. For these reasons, the safety of ART needs to be closely examined. In this review, from an ART safety standpoint, the origins of OS are reviewed, and the long-lasting cardiovascular effects and potential mechanisms of OS on the offspring are discussed. View Full-Text
Keywords: oxidative stress; long-lasting; cardiovascular; assisted reproductive technologies; offspring oxidative stress; long-lasting; cardiovascular; assisted reproductive technologies; offspring
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MDPI and ACS Style

Yang, H.; Kuhn, C.; Kolben, T.; Ma, Z.; Lin, P.; Mahner, S.; Jeschke, U.; von Schönfeldt, V. Early Life Oxidative Stress and Long-Lasting Cardiovascular Effects on Offspring Conceived by Assisted Reproductive Technologies: A Review. Int. J. Mol. Sci. 2020, 21, 5175. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21155175

AMA Style

Yang H, Kuhn C, Kolben T, Ma Z, Lin P, Mahner S, Jeschke U, von Schönfeldt V. Early Life Oxidative Stress and Long-Lasting Cardiovascular Effects on Offspring Conceived by Assisted Reproductive Technologies: A Review. International Journal of Molecular Sciences. 2020; 21(15):5175. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21155175

Chicago/Turabian Style

Yang, Huixia, Christina Kuhn, Thomas Kolben, Zhi Ma, Peng Lin, Sven Mahner, Udo Jeschke, and Viktoria von Schönfeldt. 2020. "Early Life Oxidative Stress and Long-Lasting Cardiovascular Effects on Offspring Conceived by Assisted Reproductive Technologies: A Review" International Journal of Molecular Sciences 21, no. 15: 5175. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21155175

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