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Review

Modulating the Crosstalk between the Tumor and Its Microenvironment Using RNA Interference: A Treatment Strategy for Hepatocellular Carcinoma

1
Institute for Advanced Biosciences, Research Center Inserm U 1209/CNRS 5309, 38700 La Tronche, France
2
Université Grenoble Alpes, 38000 Grenoble, France
3
Laboratory of Cancer Biology and Molecular Immunology, Faculty of Sciences I, Lebanese University, Hadath Beirut 6573-14, Lebanon
4
Service d’hépato-Gastroentérologie, Pôle Digidune, CHU Grenoble Alpes, 38700 La Tronche, France
*
Authors to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(15), 5250; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21155250
Received: 15 June 2020 / Revised: 20 July 2020 / Accepted: 22 July 2020 / Published: 24 July 2020
Hepatocellular carcinoma (HCC) is the most common primary liver malignancy with one of the highest mortality rates among solid cancers. It develops almost exclusively in the background of chronic liver inflammation, which can be caused by viral hepatitis, chronic alcohol consumption or an unhealthy diet. Chronic inflammation deregulates the innate and adaptive immune responses that contribute to the proliferation, survival and migration of tumor cells. The continuous communication between the tumor and its microenvironment components serves as the overriding force of the tumor against the body’s defenses. The importance of this crosstalk between the tumor microenvironment and immune cells in the process of hepatocarcinogenesis has been shown, and therapeutic strategies modulating this communication have improved the outcomes of patients with liver cancer. To target this communication, an RNA interference (RNAi)-based approach can be used, an innovative and promising strategy that can disrupt the crosstalk at the transcriptomic level. Moreover, RNAi offers the advantage of specificity in comparison to the treatments currently used for HCC in clinics. In this review, we will provide the recent data pertaining to the modulation of a tumor and its microenvironment by using RNAi and its potential for therapeutic intervention in HCC. View Full-Text
Keywords: HCC; tumor microenvironment; RNAi; miRNA; shRNA; siRNA HCC; tumor microenvironment; RNAi; miRNA; shRNA; siRNA
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MDPI and ACS Style

Mroweh, M.; Decaens, T.; Marche, P.N.; Macek Jilkova, Z.; Clément, F. Modulating the Crosstalk between the Tumor and Its Microenvironment Using RNA Interference: A Treatment Strategy for Hepatocellular Carcinoma. Int. J. Mol. Sci. 2020, 21, 5250. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21155250

AMA Style

Mroweh M, Decaens T, Marche PN, Macek Jilkova Z, Clément F. Modulating the Crosstalk between the Tumor and Its Microenvironment Using RNA Interference: A Treatment Strategy for Hepatocellular Carcinoma. International Journal of Molecular Sciences. 2020; 21(15):5250. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21155250

Chicago/Turabian Style

Mroweh, Mariam, Thomas Decaens, Patrice N. Marche, Zuzana Macek Jilkova, and Flora Clément. 2020. "Modulating the Crosstalk between the Tumor and Its Microenvironment Using RNA Interference: A Treatment Strategy for Hepatocellular Carcinoma" International Journal of Molecular Sciences 21, no. 15: 5250. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21155250

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