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Review

Epigenetic Mechanisms Underlying Adult Post Stroke Neurogenesis

1
Department of Neurology, Henry Ford Health System, Detroit, MI 48202, USA
2
Department of Physics, Oakland University, Rochester, MI 48309, USA
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(17), 6179; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21176179
Received: 23 July 2020 / Revised: 24 August 2020 / Accepted: 25 August 2020 / Published: 27 August 2020
(This article belongs to the Special Issue Neuroregeneration and Brain Repair after Stroke)
Stroke remains the leading cause of adult disability. Post-stroke neurogenesis contributes to functional recovery. As an intrinsic neurorestorative process, it is important to elucidate the molecular mechanism underlying stroke-induced neurogenesis and to develop therapies designed specifically to augment neurogenesis. Epigenetic mechanisms include DNA methylation, histone modification and its mediation by microRNAs and long-non-coding RNAs. In this review, we highlight how epigenetic factors including DNA methylation, histone modification, microRNAs and long-non-coding RNAs mediate stroke-induced neurogenesis including neural stem cell self-renewal and cell fate determination. We also summarize therapies targeting these mechanisms in the treatment of stroke. View Full-Text
Keywords: stroke; epigenetics; microRNAs; histone deacetylation; adult neurogenesis; long non-coding RNA stroke; epigenetics; microRNAs; histone deacetylation; adult neurogenesis; long non-coding RNA
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MDPI and ACS Style

Liu, X.; Fan, B.; Chopp, M.; Zhang, Z. Epigenetic Mechanisms Underlying Adult Post Stroke Neurogenesis. Int. J. Mol. Sci. 2020, 21, 6179. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21176179

AMA Style

Liu X, Fan B, Chopp M, Zhang Z. Epigenetic Mechanisms Underlying Adult Post Stroke Neurogenesis. International Journal of Molecular Sciences. 2020; 21(17):6179. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21176179

Chicago/Turabian Style

Liu, Xianshuang, Baoyan Fan, Michael Chopp, and Zhenggang Zhang. 2020. "Epigenetic Mechanisms Underlying Adult Post Stroke Neurogenesis" International Journal of Molecular Sciences 21, no. 17: 6179. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21176179

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