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Review

Molecular Basis of Inflammation in the Pathogenesis of Cardiomyopathies

1
Department of Translational Medical Sciences, University of Campania “Luigi Vanvitelli”, 80131 Naples, Italy
2
Dipartimento di Medicina Molecolaree Biotecnologie Mediche, University of Naples “Federico II”, 80138 Naples, Italy
3
CEINGE-Biotecnologie Avanzate Scarl, Via G. Salvatore 486, 80138 Naples, Italy
4
Task Force sugli Studi del Microbioma, University of Naples “Federico II”, 80138 Naples, Italy
5
Institute of Cardiovascular Sciences, University College of London and St. Bartholomew’s Hospital, London WC1E 6DD, UK
*
Author to whom correspondence should be addressed.
Member of ERN GUARD-HEART (European Reference Network for Rare and Complex Diseases of the Heart).
Int. J. Mol. Sci. 2020, 21(18), 6462; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21186462
Received: 7 August 2020 / Revised: 25 August 2020 / Accepted: 2 September 2020 / Published: 4 September 2020
(This article belongs to the Special Issue Biomolecular Mediators in Cardiomyopathies)
Cardiomyopathies (CMPs) represent a diverse group of heart muscle diseases, grouped into specific morphological and functional phenotypes. CMPs are associated with mutations in sarcomeric and non-sarcomeric genes, with several suspected epigenetic and environmental mechanisms involved in determining penetrance and expressivity. The understanding of the underlying molecular mechanisms of myocardial diseases is fundamental to achieving a proper management and treatment of these disorders. Among these, inflammation seems to play an important role in the pathogenesis of CMPs. The aim of the present study is to review the current knowledge on the role of inflammation and the immune system activation in the pathogenesis of CMPs and to identify potential molecular targets for a tailored anti-inflammatory treatment. View Full-Text
Keywords: inflammation; cardiomyopathies; pathogenesis inflammation; cardiomyopathies; pathogenesis
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MDPI and ACS Style

Monda, E.; Palmiero, G.; Rubino, M.; Verrillo, F.; Amodio, F.; Di Fraia, F.; Pacileo, R.; Fimiani, F.; Esposito, A.; Cirillo, A.; Fusco, A.; Moscarella, E.; Frisso, G.; Russo, M.G.; Pacileo, G.; Calabrò, P.; Scudiero, O.; Caiazza, M.; Limongelli, G. Molecular Basis of Inflammation in the Pathogenesis of Cardiomyopathies. Int. J. Mol. Sci. 2020, 21, 6462. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21186462

AMA Style

Monda E, Palmiero G, Rubino M, Verrillo F, Amodio F, Di Fraia F, Pacileo R, Fimiani F, Esposito A, Cirillo A, Fusco A, Moscarella E, Frisso G, Russo MG, Pacileo G, Calabrò P, Scudiero O, Caiazza M, Limongelli G. Molecular Basis of Inflammation in the Pathogenesis of Cardiomyopathies. International Journal of Molecular Sciences. 2020; 21(18):6462. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21186462

Chicago/Turabian Style

Monda, Emanuele, Giuseppe Palmiero, Marta Rubino, Federica Verrillo, Federica Amodio, Francesco Di Fraia, Roberta Pacileo, Fabio Fimiani, Augusto Esposito, Annapaola Cirillo, Adelaide Fusco, Elisabetta Moscarella, Giulia Frisso, Maria G. Russo, Giuseppe Pacileo, Paolo Calabrò, Olga Scudiero, Martina Caiazza, and Giuseppe Limongelli. 2020. "Molecular Basis of Inflammation in the Pathogenesis of Cardiomyopathies" International Journal of Molecular Sciences 21, no. 18: 6462. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21186462

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