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Review

The Transcription Factor TCF1 in T Cell Differentiation and Aging

1
Division of Immunology and Rheumatology, Department of Medicine, Stanford University, Stanford, CA 94305-5166, USA
2
Department of Medicine, Palo Alto Veterans Administration Healthcare System, Palo Alto, CA 94304, USA
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(18), 6497; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21186497
Received: 19 August 2020 / Revised: 29 August 2020 / Accepted: 3 September 2020 / Published: 5 September 2020
(This article belongs to the Special Issue Recent Advances in T Cell Immunity)
The transcription factor T cell factor 1 (TCF1), a pioneer transcription factor as well as a downstream effector of WNT/β-catenin signaling, is indispensable for T cell development in the thymus. Recent studies have highlighted the additional critical role of TCF1 in peripheral T cell responses to acute and chronic infections as well as cancer. Here, we review the regulatory functions of TCF1 in the differentiation of T follicular helper cells, memory T cells and recently described stem-like exhausted T cells, where TCF1 promotes less differentiated stem-like cell states by controlling common gene-regulatory networks. These studies also provide insights into the mechanisms of defective T cell responses in older individuals. We discuss alterations in TCF1 expression and related regulatory networks with age and their consequences for T cell responses to infections and vaccination. The increasing understanding of the pathways regulating TCF1 expression and function in aged T cells holds the promise of enabling the design of therapeutic interventions aiming at improving T cell responses in older individuals. View Full-Text
Keywords: TCF1; WNT/β-catenin; T cell aging; T cell differentiation; memory T cells; T follicular helper cells; T cell exhaustion; stem-like CD8 T cells; immunosenescence TCF1; WNT/β-catenin; T cell aging; T cell differentiation; memory T cells; T follicular helper cells; T cell exhaustion; stem-like CD8 T cells; immunosenescence
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MDPI and ACS Style

Kim, C.; Jin, J.; Weyand, C.M.; Goronzy, J.J. The Transcription Factor TCF1 in T Cell Differentiation and Aging. Int. J. Mol. Sci. 2020, 21, 6497. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21186497

AMA Style

Kim C, Jin J, Weyand CM, Goronzy JJ. The Transcription Factor TCF1 in T Cell Differentiation and Aging. International Journal of Molecular Sciences. 2020; 21(18):6497. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21186497

Chicago/Turabian Style

Kim, Chulwoo, Jun Jin, Cornelia M. Weyand, and Jörg J. Goronzy 2020. "The Transcription Factor TCF1 in T Cell Differentiation and Aging" International Journal of Molecular Sciences 21, no. 18: 6497. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21186497

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